Human Chromobox Homolog 2 (CBX2) ELISA Kit | CBX2 elisa kit
Human Chromobox Homolog 2 (CBX2) ELISA Kit
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a component of the polycomb multiprotein complex, which is required to maintain the transcriptionally repressive state of many genes throughout development via chromatin remodeling and modification of histones. Disruption of this gene in mice results in male-to-female gonadal sex reversal. Mutations in this gene are also associated with gonadal dysgenesis in humans. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene.[provided by RefSeq, Mar 2010]
Uniprot Description
CBX2: Component of a Polycomb group (PcG) multiprotein PRC1- like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. Involved in sexual development, acting as activator of NR5A1 expression. Defects in CBX2 are the cause of 46,XY sex reversal type 5 (SRXY5). It is a disorder of sex development. Affected individuals have a 46,XY karyotype but present as phenotypically normal females. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Transcription regulation
Chromosomal Location of Human Ortholog: 17q25.3
Cellular Component: nucleoplasm; heterochromatin; euchromatin; PcG protein complex; nucleus
Molecular Function: protein binding; DNA binding; chromatin binding; methylated histone residue binding
Biological Process: transcription, DNA-dependent; chromatin modification; negative regulation of transcription from RNA polymerase II promoter; cell differentiation; development of primary sexual characteristics
Disease: 46,xy Sex Reversal 5
Research Articles on CBX2
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Product Notes
The Human CBX2 cbx2 (Catalog #AAA9303185) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9303185 ELISA Kit recognizes Human CBX2. It is sometimes possible for the material contained within the vial of "Chromobox Homolog 2 (CBX2), ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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