Cat Chemokine Interferon-Inducible Protein 8 ELISA Kit | IP-8 elisa kit
Cat Chemokine Interferon-Inducible Protein 8 ELISA Kit
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a G protein-coupled receptor with selectivity for three chemokines, termed CXCL9/Mig (monokine induced by interferon-g), CXCL10/IP10 (interferon-g-inducible 10 kDa protein) and CXCL11/I-TAC (interferon-inducible T cell a-chemoattractant). Binding of chemokines to this protein induces cellular responses that are involved in leukocyte traffic, most notably integrin activation, cytoskeletal changes and chemotactic migration. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. One of the isoforms (CXCR3-B) shows high affinity binding to chemokine, CXCL4/PF4 (PMID:12782716). [provided by RefSeq, Jun 2011]
Uniprot Description
CXCR3: Receptor for CXCL9, CXCL10 and CXCL11 and mediates the proliferation of human mesangial cells (HMC). Belongs to the G-protein coupled receptor 1 family. 3 isoforms of the human protein are produced by alternative splicing.
Protein type: Receptor, GPCR; Membrane protein, integral; Membrane protein, multi-pass; GPCR, family 1
Chromosomal Location of Human Ortholog: Xq13
Cellular Component: integral to plasma membrane; cytoplasm; plasma membrane; external side of plasma membrane
Molecular Function: C-X-C chemokine binding; chemokine receptor activity; chemokine binding; receptor activity; C-X-C chemokine receptor activity
Biological Process: positive regulation of chemotaxis; apoptosis; calcium-mediated signaling; positive regulation of cAMP metabolic process; chemotaxis; G-protein coupled receptor protein signaling pathway; positive regulation of angiogenesis; elevation of cytosolic calcium ion concentration; negative regulation of angiogenesis; cell surface receptor linked signal transduction; regulation of leukocyte migration; positive regulation of cell proliferation; negative regulation of endothelial cell proliferation; positive regulation of transcription from RNA polymerase II promoter; positive regulation of release of sequestered calcium ion into cytosol; angiogenesis; inflammatory response; cell motility; cell adhesion