Casc3 blocking peptide

CASC3 Blocking Peptide (C-term)

• Gene Names: Casc3; Btz; Mln51
• Synonyms: CASC3; CASC3 Blocking Peptide (C-term); Protein CASC3; Cancer susceptibility candidate gene 3 protein homolog; Metastatic lymph node gene 51 protein homolog; MLN 51 homolog; Protein barentsz; Btz; mBtz; Casc3; Mln51; Casc3 blocking peptide

• Specificity: The synthetic peptide sequence is selected from aa 217-233 of MOUSE Casc3
• Form/Format: Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
• Sequence Length: 698

• Cellular Location: Cytoplasm, perinuclear region. Nucleus. Nucleus speckle Note: Travels to the cytoplasm as part of the exon junction complex (EJC) bound to mRNA. Shuttles between the cytoplasm and the stress granules. More specifically found in nuclear intrachromatin granules clusters (IGC), also called nuclear speckles, which are storage compartments for nuclear proteins involved in mRNA processing. Colocalizes in nuclear speckles with MAGOH. Under stress condition, colocalizes with FMR1 and TIA1, but not MAGOH and RBM8A EJC core factors, in cytoplasmic stress granules, which contain stored mRNAs whose translation is stopped in response to stress (By similarity). Predominantly found in the perinuclear region. Shuttles between the nucleus and the cytoplasm in a CRM1- dependent manner.
• Tissue Location: High levels in heart, brain, including hippocampus and cerebellum, liver, kidney and testis; lower levels in muscle, lung and spleen.
• Preparation and Storage: Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.

Related Product Information for Casc3 blocking peptide

Core component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junctions on mRNAs. The EJC is a dynamic structure consisting of core proteins and several peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. The EJC marks the position of the exon-exon junction in the mature mRNA for the gene expression machinery and the core components remain bound to spliced mRNAs throughout all stages of mRNA metabolism thereby influencing downstream processes including nuclear mRNA export, subcellular mRNA localization, translation efficiency and nonsense-mediated mRNA decay (NMD). Stimulates the ATPase and RNA- helicase activities of EIF4A3. Plays a role in the stress response by participating in cytoplasmic stress granules assembly and by favoring cell recovery following stress. Component of the dendritic ribonucleoprotein particles (RNPs) in hippocampal neurons. May play a role in mRNA transport. Binds spliced mRNA in sequence-independent manner, 20-24 nucleotides upstream of mRNA exon-exon junctions. Binds poly(G) and poly(U) RNA homopolymer (By similarity).

NCBI and Uniprot Product Information

• NCBI GI #: 160333568
• NCBI GeneID: 192160
• NCBI Accession #: NP_619601
• NCBI GenBank Nucleotide #: NM_138660.2
• UniProt Accession #: Q8K3W3; Q3UT99; Q8K219; Q99NF0; A3KFP7
• Molecular Weight: 75,770 Da
• NCBI Official Full Name: protein CASC3
• NCBI Official Synonym Full Names: cancer susceptibility candidate 3
• NCBI Official Symbol: Casc3
• NCBI Official Synonym Symbols: Btz; Mln51
• NCBI Protein Information: protein CASC3
• UniProt Protein Name: Protein CASC3
• Protein Family: Protein
• UniProt Gene Name: Casc3
• UniProt Synonym Gene Names: Mln51; MLN 51 homolog; Btz; mBtz
• UniProt Entry Name: CASC3_MOUSE

Uniprot Description

CASC3: Component of a splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junction on mRNAs. The EJC is a dynamic structure consisting of a few core proteins and several more peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. Core components of the EJC, that remains bound to spliced mRNAs throughout all stages of mRNA metabolism, functions to mark the position of the exon-exon junction in the mature mRNA and thereby influences downstream processes of gene expression including mRNA splicing, nuclear mRNA export, subcellular mRNA localization, translation efficiency and nonsense-mediated mRNA decay (NMD). Stimulates the ATPase and RNA- helicase activities of EIF4A3. Plays a role in the stress response by participating in cytoplasmic stress granules assembly and by favoring cell recovery following stress. Component of the dendritic ribonucleoprotein particles (RNPs) in hippocampal neurons. May play a role in mRNA transport. Binds spliced mRNA in sequence-independent manner, 20-24 nucleotides upstream of mRNA exon-exon junctions. Binds poly(G) and poly(U) RNA homopolymer. Belongs to the CASC3 family.

Protein type: Translation; RNA-binding

Cellular Component: cytoplasm; nucleus; ribonucleoprotein complex

Molecular Function: enzyme binding; identical protein binding; protein binding; ubiquitin protein ligase binding

Biological Process: intracellular mRNA localization; RNA metabolic process