PIK3C2B (Y228) Blocking Peptide | PIK3C2B blocking peptide

Phospho-HUMAN-PIK3C2B(Y228) Blocking Peptide

• Gene Names: PIK3C2B; C2-PI3K
• Synonyms: PIK3C2B (Y228); Phospho-HUMAN-PIK3C2B(Y228) Blocking Peptide; Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta; PI3K-C2-beta; PtdIns-3-kinase C2 subunit beta; C2-PI3K; Phosphoinositide 3-kinase-C2-beta; PIK3C2B; PIK3C2B blocking peptide

• Specificity: The synthetic peptide sequence is selected from aa 215-230 of HUMAN PIK3C2B
• Form/Format: Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
• Sequence Length: 1634

• Cellular Location: Microsome. Cell membrane. Cytoplasm, cytosol. Nucleus. Endoplasmic reticulum. Note: Found mostly in the microsome, but also in the plasma membrane and cytosol. Nuclear in testis
• Tissue Location: Expressed in columnar and transitional epithelia, mononuclear cells, and ganglion cells (at protein level). Widely expressed, with highest levels in thymus and placenta and lowest in peripheral blood, skeletal muscle and kidney.
• Preparation and Storage: Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.

Related Product Information for PIK3C2B blocking peptide

Phosphorylates PtdIns and PtdIns4P with a preference for PtdIns. Does not phosphorylate PtdIns(4,5)P2. May be involved in EGF and PDGF signaling cascades.

NCBI and Uniprot Product Information

• NCBI GI #: 73920246
• NCBI GeneID: 5287
• UniProt Accession #: O00750; O95666; Q5SW99
• Molecular Weight: 184,768 Da
• NCBI Official Full Name: Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta
• NCBI Official Synonym Full Names: phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 beta
• NCBI Official Symbol: PIK3C2B
• NCBI Official Synonym Symbols: C2-PI3K
• NCBI Protein Information: phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta
• UniProt Protein Name: Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta
• Protein Family: Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing
• UniProt Gene Name: PIK3C2B
• UniProt Synonym Gene Names: PI3K-C2-beta; PtdIns-3-kinase C2 subunit beta
• UniProt Entry Name: P3C2B_HUMAN

NCBI Description

The protein encoded by this gene belongs to the phosphoinositide 3-kinase (PI3K) family. PI3-kinases play roles in signaling pathways involved in cell proliferation, oncogenic transformation, cell survival, cell migration, and intracellular protein trafficking. This protein contains a lipid kinase catalytic domain as well as a C-terminal C2 domain, a characteristic of class II PI3-kinases. C2 domains act as calcium-dependent phospholipid binding motifs that mediate translocation of proteins to membranes, and may also mediate protein-protein interactions. The PI3-kinase activity of this protein is sensitive to low nanomolar levels of the inhibitor wortmanin. The C2 domain of this protein was shown to bind phospholipids but not Ca2+, which suggests that this enzyme may function in a calcium-independent manner. [provided by RefSeq, Jul 2008]

Uniprot Description

PIK3C2B: Phosphorylates PtdIns and PtdIns4P with a preference for PtdIns. Does not phosphorylate PtdIns(4,5)P2. May be involved in EGF and PDGF signaling cascades. Belongs to the PI3/PI4-kinase family.

Protein type: EC 2.7.1.154; Kinase, lipid; Motility/polarity/chemotaxis; Carbohydrate Metabolism - inositol phosphate

Chromosomal Location of Human Ortholog: 1q32

Cellular Component: cytosol; phosphoinositide 3-kinase complex; plasma membrane

Molecular Function: 1-phosphatidylinositol-3-kinase activity; phosphatidylinositol-4-phosphate 3-kinase activity; protein binding

Biological Process: phosphatidylinositol biosynthetic process