PSME4 blocking peptide

PSME4 Blocking Peptide (N-Term)

• Synonyms: PSME4; PSME4 Blocking Peptide (N-Term); Proteasome activator complex subunit 4; Proteasome activator PA200; KIAA0077; PSME4 blocking peptide

• Specificity: The synthetic peptide sequence is selected from aa 523-535 of HUMAN PSME4
• Form/Format: Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
• Sequence Length: 1845

• Cellular Location: Cytoplasm, cytosol. Nucleus. Nucleus speckle Note: Found in nuclear foci following treatment with ionizing radiation, but not with ultraviolet irradiation or H(2)O(2)
• Preparation and Storage: Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.

Related Product Information for PSME4 blocking peptide

Associated component of the proteasome that specifically recognizes acetylated histones and promotes ATP- and ubiquitin- independent degradation of core histones during spermatogenesis and DNA damage response. Recognizes and binds acetylated histones via its bromodomain-like (BRDL) region and activates the proteasome by opening the gated channel for substrate entry. Binds to the core proteasome via its C-terminus, which occupies the same binding sites as the proteasomal ATPases, opening the closed structure of the proteasome via an active gating mechanism. Component of the spermatoproteasome, a form of the proteasome specifically found in testis: binds to acetylated histones and promotes degradation of histones, thereby participating actively to the exchange of histones during spermatogenesis. Also involved in DNA damage response in somatic cells, by promoting degradation of histones following DNA double-strand breaks.

NCBI and Uniprot Product Information

• NCBI GI #: 528050049
• NCBI GeneID: 528142
• UniProt Accession #: Q14997; F1MKX4
• Molecular Weight: 211,600 Da
• NCBI Official Full Name: Proteasome activator complex subunit 4
• NCBI Official Symbol: PSME4
• NCBI Protein Information: proteasome activator complex subunit 4
• UniProt Protein Name: Proteasome activator complex subunit 4
• Protein Family: Proteasome activator complex
• UniProt Gene Name: PSME4
• UniProt Entry Name: PSME4_BOVIN

Uniprot Description

Associated component of the proteasome that specifically recognizes acetylated histones and promotes ATP- and ubiquitin-independent degradation of core histones during spermatogenesis and DNA damage response. Recognizes and binds acetylated histones via its bromodomain-like (BRDL) region and activates the proteasome by opening the gated channel for substrate entry. Binds to the core proteasome via its C-terminus, which occupies the same binding sites as the proteasomal ATPases, opening the closed structure of the proteasome via an active gating mechanism. Component of the spermatoproteasome, a form of the proteasome specifically found in testis: binds to acetylated histones and promotes degradation of histones, thereby participating actively to the exchange of histones during spermatogenesis. Also involved in DNA damage response in somatic cells, by promoting degradation of histones following DNA double-strand breaks ().