RNF126 Blocking Peptide | RNF126 (HGNC:21151) blocking peptide

RNF126 Blocking Peptide (Center)

• Synonyms: RNF126; RNF126 Blocking Peptide (Center); E3 ubiquitin-protein ligase RNF126; 632-; RING finger protein 126; RNF126 (HGNC:21151) blocking peptide

• Specificity: The synthetic peptide sequence is selected from aa 104-115 of HUMAN RNF126 (HGNC:21151)
• Form/Format: Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
• Sequence Length: 326

• Cellular Location: Cytoplasm. Nucleus
• Tissue Location: Highly expressed in liver and testis.
• Preparation and Storage: Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.

Related Product Information for RNF126 (HGNC:21151) blocking peptide

E3 ubiquitin-protein ligase that regulates several biological processes through ubiquitination of various target proteins. Depending on the associated E2 ligase, mediates 'Lys- 48'- and 'Lys-63'-linked polyubiquitination of substrates. Through their polyubiquitination, may play a role in the endosomal sorting and degradation of several membrane receptors including EGFR, FLT3, MET and CXCR4. May also be part of a BAG6-dependent quality control process ensuring that proteins of the secretory pathway that are mislocalized to the cytosol are degraded by the proteasome. May provide the ubiquitin ligase activity associated with the BAG6 complex and be responsible for ubiquitination of the mislocalized proteins and their targeting to the proteasome (PubMed:24981174). May also play a role in the endosomal recycling of IGF2R, the cation-independent mannose-6-phosphate receptor (PubMed:24275455). By ubiquitinating CDKN1A/p21 and targeting it for degradation, may also promote cell proliferation (PubMed:23026136). May monoubiquitinate AICDA (PubMed:23277564).

NCBI and Uniprot Product Information

• NCBI GI #: 74762712
• NCBI GeneID: 55658
• UniProt Accession #: Q9BV68; Q9NWX1
• Molecular Weight: 33,861 Da
• NCBI Official Full Name: E3 ubiquitin-protein ligase RNF126
• NCBI Official Synonym Full Names: ring finger protein 126
• NCBI Official Symbol: RNF126
• NCBI Protein Information: E3 ubiquitin-protein ligase RNF126
• UniProt Protein Name: E3 ubiquitin-protein ligase RNF126
• UniProt Gene Name: RNF126
• UniProt Entry Name: RN126_HUMAN

NCBI Description

The protein encoded by this gene contains a RING finger domain, a motif present in a variety of functionally distinct proteins and known to be involved in protein-protein and protein-DNA interactions. [provided by RefSeq, Jul 2008]

Uniprot Description

RNF126: 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Ubiquitin ligase; EC 6.3.2.19; Ubiquitin conjugating system

Chromosomal Location of Human Ortholog: 19p13.3

Cellular Component: cytoplasm; nucleus

Molecular Function: protein binding

Biological Process: negative regulation of epidermal growth factor receptor signaling pathway; proteasomal ubiquitin-dependent protein catabolic process; protein monoubiquitination; protein polyubiquitination; protein ubiquitination during ubiquitin-dependent protein catabolic process; regulation of cell proliferation; retrograde transport, endosome to Golgi; ubiquitin-dependent protein catabolic process via the multivesicular body pathway