ABCA2 blocking peptide

ABCA2 Blocking Peptide (Center)

Gene Names

ABCA2; ABC2

Synonyms

ABCA2; ABCA2 Blocking Peptide (Center); ATP-binding cassette sub-family A member 2; ATP-binding cassette transporter 2; ATP-binding cassette 2; ABC2; KIAA1062; ABCA2 blocking peptide

Ordering

Specificity

The synthetic peptide sequence is selected from aa 1339-1353 of HUMAN ABCA2

Form/Format

Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.

Sequence Length

2435

Cellular Location

Endosome membrane; Multi-pass membrane protein. Lysosome membrane; Multi-pass membrane protein. Note: Forms discrete, punctate intracellular vesicles

Tissue Location

Highly expressed in the brain, whereas lower levels of expression is observed in kidney and liver

Preparation and Storage

Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.

Related Product Information for ABCA2 blocking peptide

Probable transporter, its natural substrate has not been found yet. May have a role in macrophage lipid metabolism and neural development.

NCBI and Uniprot Product Information

NCBI GI #

206729923

NCBI GeneID

UniProt Accession #

Q9BZC7; Q5SPY5; Q5W9G5; Q76MW7; Q9HC28; A6NED5

Molecular Weight

269,988 Da

NCBI Official Full Name

ATP-binding cassette sub-family A member 2

NCBI Official Synonym Full Names

ATP binding cassette subfamily A member 2

NCBI Official Symbol

ABCA2

NCBI Official Synonym Symbols

ABC2

NCBI Protein Information

ATP-binding cassette sub-family A member 2

UniProt Protein Name

ATP-binding cassette sub-family A member 2

Protein Family

ABC transporter A family

UniProt Gene Name

ABCA2

UniProt Synonym Gene Names

ABC2; KIAA1062; ATP-binding cassette 2

UniProt Entry Name

ABCA2_HUMAN

NCBI Description

The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intracellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the ABC1 subfamily. Members of the ABC1 subfamily comprise the only major ABC subfamily found exclusively in multicellular eukaryotes. This protein is highly expressed in brain tissue and may play a role in macrophage lipid metabolism and neural development. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Uniprot Description

ABCA2: Probable transporter, its natural substrate has not been found yet. May have a role in macrophage lipid metabolism and neural development. Belongs to the ABC transporter superfamily. ABCA family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, multi-pass; Membrane protein, integral; Transporter, ABC family; Transporter

Chromosomal Location of Human Ortholog: 9q34

Cellular Component: cytoplasmic membrane-bound vesicle; endosome; integral to membrane; lysosome; membrane; microtubule organizing center

Molecular Function: ATP binding; ATPase activity; ATPase activity, coupled to transmembrane movement of substances

Biological Process: cholesterol efflux; cholesterol homeostasis; phospholipid efflux; regulation of intracellular cholesterol transport; regulation of transcription from RNA polymerase II promoter; response to drug; response to steroid hormone stimulus

Research Articles on ABCA2

1. Our findings indicate a considerable and direct relationship between mRNA expression levels of ABCA2, ABCA3, MDR1, and MRP1 genes and positive minimal residual disease (MRD) measured after one year of treatment.

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Product Notes

The ABCA2 abca2 (Catalog #AAA9229692) is a Blocking Peptide and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "ABCA2, Blocking Peptide" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.

Precautions

All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.

Disclaimer

Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.

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ABCA2 blocking peptide