Sqstm1 (S351) Blocking Peptide | Sqstm1 blocking peptide

Sqstm1(S351) Blocking Peptide

• Gene Names: Sqstm1; Osi; p62; A170; STAP; OSF-6; STONE14
• Synonyms: Sqstm1 (S351); Sqstm1(S351) Blocking Peptide; Sequestosome-1; STONE14; Ubiquitin-binding protein p62; Sqstm1; A170; STAP; Sqstm1 blocking peptide

• Specificity: The synthetic peptide sequence is selected from aa 346-359 of HUMAN Sqstm1
• Form/Format: Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
• Sequence Length: 442

• Cellular Location: Cytoplasm. Late endosome. Nucleus. Endoplasmic reticulum. Lysosome. Cytoplasmic vesicle, autophagosome. Cytoplasm, P-body. Note: Sarcomere. In cardiac muscles localizes to the sarcomeric band. May also localize to the hepatocellular carcinoma. Colocalizes with TRIM13 in the perinuclear endoplasmic reticulum (By similarity). Commonly found in inclusion bodies containing polyubiquitinated protein aggregates (By similarity) Co-localizes with TRIM5 in the cytoplasmic bodies (By similarity)
• Tissue Location: Widely expressed.
• Preparation and Storage: Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.

Related Product Information for Sqstm1 blocking peptide

Autophagy receptor that interacts directly with both the cargo to become degraded and an autophagy modifier of the MAP1 LC3 family. Required both for the formation and autophagic degradation of polyubiquitin-containing bodies, called ALIS (aggresome-like induced structures) and links ALIS to the autophagic machinery. Involved in midbody ring degradation. May regulate the activation of NFKB1 by TNF-alpha, nerve growth factor (NGF) and interleukin- 1. May play a role in titin/TTN downstream signaling in muscle cells. May regulate signaling cascades through ubiquitination. May be involved in cell differentiation, apoptosis, immune response and regulation of K(+) channels. Adapter that mediates the interaction between TRAF6 and CYLD.

NCBI and Uniprot Product Information

• NCBI GI #: 77416573
• NCBI GeneID: 18412
• UniProt Accession #: Q64337; Q99JM8
• Molecular Weight: 44,192 Da
• NCBI Official Full Name: Sequestosome-1
• NCBI Official Synonym Full Names: sequestosome 1
• NCBI Official Symbol: Sqstm1
• NCBI Official Synonym Symbols: Osi; p62; A170; STAP; OSF-6; STONE14
• NCBI Protein Information: sequestosome-1
• UniProt Protein Name: Sequestosome-1
• Protein Family: Sequestosome
• UniProt Gene Name: Sqstm1
• UniProt Synonym Gene Names: A170; STAP
• UniProt Entry Name: SQSTM_MOUSE

Uniprot Description

SQSTM1: an adapter protein which binds ubiquitin, shuttling proteins to the proteasome. Co-localizes along with the E3 ubiquitin ligase, TRAF6, to aggregates from Alzheimer's disease brains but not in control brain. May regulate the activation of NFKB1 by TNF-alpha, nerve growth factor (NGF) and interleukin-1. May play a role in titin downstream signaling in muscle cells. May regulate signaling cascades through ubiquitination. May be involved in cell differentiation, apoptosis, immune response and regulation of K(+) channels. Forms ternary complexes with PKCZ and Kv-beta2 or PKCZ and GABBR3. Also interacts with KCNAB1, GABRR1, GABRR2 and GABRR3. Interacts with EBI3, LCK, RASA1, PKCZ , PKCI, NR2F2, NTRK1, NTRK2, NTRK3, NBR1, MEK5, TRIM55 and MAPKAPK5. Interacts with the proteasome subunits PSMD4 and PSMC2. Interacts with K63- polyubiquitinated MAPT/TAU. Interacts with IKBKB through PRKCZ and PRKCI. Interacts with NGFR through TRAF6 and bridges that complex to NTRK1. Forms a complex with MEK5 and PRKCZ or PRKCI. Component of a ternary complex with PAWR and PRKCZ. Upon TNF-alpha stimulation, interacts with RIPK1 problably bridging IKBKB to the TNF-R1 complex composed of TNF-R1/TNFRSF1A, TRADD and RIPK1. Forms a complex with JUB/Ajuba, PRKCZ and TRAF6. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Autophagy; Ubiquitin conjugating system; Nuclear receptor co-regulator

Cellular Component: autophagic vacuole; cytoplasm; inclusion body; PML body

Molecular Function: identical protein binding; protein binding; protein homodimerization activity; protein kinase binding; protein kinase C binding; SH2 domain binding; transcription cofactor activity; ubiquitin binding; ubiquitin protein ligase binding

Biological Process: autophagy; negative regulation of transcription from RNA polymerase II promoter; positive regulation of macroautophagy; positive regulation of protein amino acid phosphorylation; protein heterooligomerization; regulation of I-kappaB kinase/NF-kappaB cascade; ubiquitin-dependent protein catabolic process