RBPMS blocking peptide

RBPMS Blocking Peptide (C-term)

• Gene Names: RBPMS; HERMES
• Synonyms: RBPMS; RBPMS Blocking Peptide (C-term); RNA-binding protein with multiple splicing; RBP-MS; Heart and RRM expressed sequence; Hermes; HERMES; RBPMS blocking peptide

• Form/Format: Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
• Sequence Length: 196

• Cellular Location: Nucleus. Cytoplasm
• Tissue Location: Ubiquitously expressed, at various levels depending on the isoform and the tissue
• Preparation and Storage: Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.

Related Product Information for RBPMS blocking peptide

Acts as a coactivator of transcriptional activity. Required to increase TGFB1/Smad-mediated transactivation. Acts through SMAD2, SMAD3 and SMAD4 to increase transcriptional activity. Increases phosphorylation of SMAD2 and SMAD3 on their C- terminal SSXS motif, possibly through recruitment of TGFBR1. Promotes the nuclear accumulation of SMAD2, SMAD3 and SMAD4 proteins. Binds to poly(A) RNA.

NCBI and Uniprot Product Information

• NCBI GI #: 13124469
• NCBI GeneID: 11030
• UniProt Accession #: Q93062; Q92516; Q92517; Q92518; Q96J26; D3DSU9
• Molecular Weight: 17,022 Da
• NCBI Official Full Name: RNA-binding protein with multiple splicing
• NCBI Official Synonym Full Names: RNA binding protein with multiple splicing
• NCBI Official Symbol: RBPMS
• NCBI Official Synonym Symbols: HERMES
• NCBI Protein Information: RNA-binding protein with multiple splicing
• UniProt Protein Name: RNA-binding protein with multiple splicing
• Protein Family: RNA-binding protein with multiple splicing
• UniProt Gene Name: RBPMS
• UniProt Synonym Gene Names: HERMES; RBP-MS; Hermes
• UniProt Entry Name: RBPMS_HUMAN

NCBI Description

This gene encodes a member of the RNA recognition motif family of RNA-binding proteins. The RNA recognition motif is between 80-100 amino acids in length and family members contain one to four copies of the motif. The RNA recognition motif consists of two short stretches of conserved sequence, as well as a few highly conserved hydrophobic residues. The encoded protein has a single, putative RNA recognition motif in its N-terminus. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jun 2013]

Uniprot Description

RBPMS: Acts as a coactivator of transcriptional activity. Required to increase TGFB1/Smad-mediated transactivation. Acts through SMAD2, SMAD3 and SMAD4 to increase transcriptional activity. Increases phosphorylation of SMAD2 and SMAD3 on their C- terminal SSXS motif, possibly through recruitment of TGFBR1. Promotes the nuclear accumulation of SMAD2, SMAD3 and SMAD4 proteins. Binds to poly(A) RNA. 5 isoforms of the human protein are produced by alternative splicing.

Protein type: Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 8p12

Cellular Component: cytoplasm; nucleoplasm

Molecular Function: poly(A) binding; protein binding; transcription coactivator activity

Biological Process: RNA processing