Ppp1r2 blocking peptide
Rat Ppp1r2 Blocking Peptide (Center)
NCBI and Uniprot Product Information
NCBI Description
may play a role in the regulation of neurogenesis [RGD, Feb 2006]
Uniprot Description
PPP1R2: a member of the protein phosphatase inhibitor 1 family. A dopamine- and cyclic AMP-regulated neuronal phosphoprotein. Both dopaminergic and glutamatergic (NMDA) receptor stimulation regulate the extent of DARPP32 phosphorylation, but in opposite directions. Dopamine D1 receptor stimulation enhances cAMP formation, resulting in the phosphorylation of DARPP32; phosphorylated DARPP32 is a potent protein phosphatase-1 inhibitor. NMDA receptor stimulation elevates intracellular calcium, which leads to activation of calcineurin and dephosphorylation of phospho-DARPP32, thereby reducing the phosphatase-1 inhibitory activity of DARPP32. Two alternatively-spliced isoforms have been described.
Protein type: Motility/polarity/chemotaxis; Protein phosphatase, regulatory subunit; Inhibitor
Cellular Component: cytoplasm; dendritic spine; growth cone; protein phosphatase type 1 complex
Molecular Function: protein domain specific binding; protein phosphatase inhibitor activity
Biological Process: negative regulation of protein binding; regulation of phosphoprotein phosphatase activity
Research Articles on Ppp1r2
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Product Notes
The Ppp1r2 ppp1r2 (Catalog #AAA9228883) is a Blocking Peptide and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "Ppp1r2, Blocking Peptide" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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