BCL9L blocking peptide

BCL9L Blocking Peptide(N-term)

Gene Names

BCL9L; BCL9-2; DLNB11

Synonyms

BCL9L; BCL9L Blocking Peptide(N-term); B-cell CLL/lymphoma 9-like protein; B-cell lymphoma 9-like protein; BCL9-like protein; Protein BCL9-2; DLNB11; BCL9L blocking peptide

Ordering

Specificity

The synthetic peptide sequence is selected from aa 162-176 of HUMAN BCL9L

Form/Format

Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.

Sequence Length

1499

Cellular Location

Nucleus

Tissue Location

Expressed in breast, ductal and invasive ductal carcinomas of the breast, sporadic colorectal adenomas and carcinomas (at protein level). Expressed in fetal brain. Expressed in lung, amygdala, eye, prostate, pancreatic and prostate cancers, head and neck tumors and embryonal tumor

Preparation and Storage

Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.

Related Product Information for BCL9L blocking peptide

Transcriptional regulator that acts as an activator. Promotes beta-catenin transcriptional activity. Plays a role in tumorigenesis. Enhances the neoplastic transforming activity of CTNNB1 (By similarity).

NCBI and Uniprot Product Information

NCBI GI #

32698936

NCBI GeneID

283149

NCBI Accession #

NP_872363.1

NCBI GenBank Nucleotide #

NM_182557.2

UniProt Accession #

Q86UU0; Q67FY1; Q6ZWJ0; Q6ZWK2; A1A4C1

Molecular Weight

152,547 Da

NCBI Official Full Name

B-cell CLL/lymphoma 9-like protein

NCBI Official Synonym Full Names

B-cell CLL/lymphoma 9-like

NCBI Official Symbol

BCL9L

NCBI Official Synonym Symbols

BCL9-2; DLNB11

NCBI Protein Information

B-cell CLL/lymphoma 9-like protein

UniProt Protein Name

B-cell CLL/lymphoma 9-like protein

Protein Family

B-cell CLL/lymphoma 9-like protein

UniProt Gene Name

BCL9L

UniProt Synonym Gene Names

DLNB11; B-cell lymphoma 9-like protein; BCL9-like protein

UniProt Entry Name

BCL9L_HUMAN

Uniprot Description

Bcl-9L: a novel beta-catenin-interacting protein that translocates beta-catenin to the nucleus, enhancing beta-catenin mediated transcription. Can play an important role in colorectal carcinogenesis. Nuclear expression of Bcl-9L is closely associated with the high nuclear grade cancer phenotype and the expression of ErbB2/HER-2 in breast cancers.

Protein type: Transcription, coactivator/corepressor

Chromosomal Location of Human Ortholog: 11q23.3

Cellular Component: nucleolus; nucleoplasm; nucleus

Molecular Function: beta-catenin binding

Biological Process: negative regulation of transforming growth factor beta receptor signaling pathway; positive regulation of transcription from RNA polymerase II promoter; regulation of cell morphogenesis

Research Articles on BCL9L

1. The inhibition of the transcriptional activity of BCL9-2 by WWOX and HDAC3 constitutes a new molecular mechanism and provides new insight for a broad range of cancers.

Similar Products

Product Notes

The BCL9L bcl9l (Catalog #AAA9228688) is a Blocking Peptide and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "BCL9L, Blocking Peptide" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.

Precautions

All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.

Disclaimer

Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.

Loading...

BCL9L blocking peptide