SNX27 blocking peptide

SNX27 Antibody (Center) Blocking Peptide

• Gene Names: SNX27; MRT1; MY014
• Synonyms: SNX27; SNX27 Antibody (Center) Blocking Peptide; Sorting nexin-27; KIAA0488; SNX27 blocking peptide

• Form/Format: Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
• Sequence Length: 541

• Cellular Location: Early endosome membrane; Peripheral membrane protein. Cytoplasm, cytosol. Note: Localizes to immunological synapse in T-cells. In T-cells, recruited from the cytosol to sorting endosomes by phosphoinositide-3-kinase products
• Tissue Location: Widely expressed. Expressed in cells of hematopoietic origin (at protein level)
• Preparation and Storage: Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.

Related Product Information for SNX27 blocking peptide

Involved in the retrograde transport from endosome to plasma membrane, a trafficking pathway that promotes the recycling of internalized transmembrane proteins. Following internalization, endocytosed transmembrane proteins are delivered to early endosomes and recycled to the plasma membrane instead of being degraded in lysosomes. SNX27 specifically binds and directs sorting of a subset of transmembrane proteins containing a PDZ- binding motif at the C-terminus: following interaction with target transmembrane proteins, associates with the retromer complex, preventing entry into the lysosomal pathway, and promotes retromer-tubule based plasma membrane recycling. SNX27 also binds with the WASH complex. Interacts with membranes containing phosphatidylinositol-3-phosphate (PtdIns(3P)). May participate in establishment of natural killer cell polarity. Recruits CYTIP to early endosomes.

NCBI and Uniprot Product Information

• NCBI GI #: 166214988
• NCBI GeneID: 81609
• UniProt Accession #: Q96L92; Q32Q36; Q4AEJ5; Q5VWB0; Q5VWB1; Q5VWB2; Q6IPP6; Q86UB1; Q96D79; Q9H3K8
• Molecular Weight: 27,781 Da
• NCBI Official Full Name: Sorting nexin-27
• NCBI Official Synonym Full Names: sorting nexin family member 27
• NCBI Official Symbol: SNX27
• NCBI Official Synonym Symbols: MRT1; MY014
• NCBI Protein Information: sorting nexin-27
• UniProt Protein Name: Sorting nexin-27
• Protein Family: Sorting nexin
• UniProt Gene Name: SNX27
• UniProt Synonym Gene Names: KIAA0488
• UniProt Entry Name: SNX27_HUMAN

NCBI Description

This gene encodes a member of the sorting nexin family, a diverse group of cytoplasmic and membrane-associated proteins involved in endocytosis of plasma membrane receptors and protein trafficking through these compartments. All members of this protein family contain a phosphoinositide binding domain (PX domain). A highly similar protein in mouse is responsible for the specific recruitment of an isoform of serotonin 5-hydroxytryptamine 4 receptor into early endosomes, suggesting the analogous role for the human protein. [provided by RefSeq, Jul 2008]

Uniprot Description

SNX27: Involved in endocytic trafficking. In T lymphocytes, participates in endocytic recycling pathway. Recruits PSCDBP and HT4R to early endosomes. Belongs to the sorting nexin family. 4 isoforms of the human protein are produced by alternative splicing.

Protein type: Vesicle

Chromosomal Location of Human Ortholog: 1q21.3

Cellular Component: cytoplasm; early endosome; immunological synapse; nucleoplasm; retromer complex

Molecular Function: phosphatidylinositol 3-phosphate binding; protein binding

Biological Process: endosome transport; establishment of natural killer cell polarity; intracellular protein transport