INSC blocking peptide

INSC Antibody (C-term) Blocking Peptide

• Synonyms: INSC; INSC Antibody (C-term) Blocking Peptide; Protein inscuteable homolog; INSC blocking peptide

• Form/Format: Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
• Sequence Length: 579

• Cellular Location: Cytoplasm. Note: Localizes to the apical cortex of mitotic epidermal cells and to the apical side of neuronal progenitor cells.
• Tissue Location: Isoform 1 is expressed in various tissues with stronger expression in liver, kidney and small intestine. Isoform 2 is abundantly expressed in small intestine and to a lower extent in lung and pancreas.
• Preparation and Storage: Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.

Related Product Information for INSC blocking peptide

May function as an adapter linking the Par3 complex to the GPSM1/GPSM2 complex. Involved in spindle orientation during mitosis it may regulate cell proliferation and differentiation in the developing nervous system. May play a role in the asymmetric division of fibroblasts and participate in the process of stratification of the squamous epithelium.

NCBI and Uniprot Product Information

• NCBI GI #: 99028953
• NCBI GeneID: 387755
• NCBI Accession #: NP_001027024.3
• NCBI GenBank Nucleotide #: NM_001031853.4
• UniProt Accession #: Q1MX18; Q1MX19; Q3C1V6; Q4AC95; Q4AC96; Q4AC97; Q4AC98; A0PJX5
• Molecular Weight: 57,188 Da
• NCBI Official Full Name: protein inscuteable homolog isoform a
• NCBI Official Synonym Full Names: inscuteable homolog (Drosophila)
• NCBI Official Symbol: INSC
• NCBI Protein Information: protein inscuteable homolog
• UniProt Protein Name: Protein inscuteable homolog
• Protein Family: Protein inscuteable
• UniProt Gene Name: INSC
• UniProt Entry Name: INSC_HUMAN

NCBI Description

In Drosophila, neuroblasts divide asymmetrically into another neuroblast at the apical side and a smaller ganglion mother cell on the basal side. Cell polarization is precisely regulated by 2 apically localized multiprotein signaling complexes that are tethered by Inscuteable, which regulates their apical localization (Izaki et al., 2006 [PubMed 16458856]).[supplied by OMIM, Mar 2008]

Uniprot Description

INSC: May function as an adapter linking the Par3 complex to the GPSM1/GPSM2 complex. Involved in spindle orientation during mitosis it may regulate cell proliferation and differentiation in the developing nervous system. May play a role in the asymmetric division of fibroblasts and participate in the process of stratification of the squamous epithelium. 5 isoforms of the human protein are produced by alternative splicing.

Chromosomal Location of Human Ortholog: 11p15.2