CENPI blocking peptide

CENPI Antibody (Center) Blocking Peptide

• Gene Names: CENPI; LRPR1; CENP-I; FSHPRH1
• Synonyms: CENPI; CENPI Antibody (Center) Blocking Peptide; Centromere protein I; CENP-I; FSH primary response protein 1; Follicle-stimulating hormone primary response protein; Interphase centromere complex protein 19; Leucine-rich primary response protein 1; FSHPRH1; ICEN19; LRPR1; CENPI blocking peptide

• Form/Format: Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
• Sequence Length: 756

• Cellular Location: Nucleus. Chromosome, centromere. Note: Localizes exclusively in the centromeres. The CENPA-CAD complex is probably recruited on centromeres by the CENPA-NAC complex
• Preparation and Storage: Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.

Related Product Information for CENPI blocking peptide

Component of the CENPA-CAD (nucleosome distal) complex, a complex recruited to centromeres which is involved in assembly of kinetochore proteins, mitotic progression and chromosome segregation. May be involved in incorporation of newly synthesized CENPA into centromeres via its interaction with the CENPA-NAC complex. Required for the localization of CENPF, MAD1L1 and MAD2 (MAD2L1 or MAD2L2) to kinetochores. Involved in the response of gonadal tissues to follicle-stimulating hormone.

NCBI and Uniprot Product Information

• NCBI GI #: 77416860
• NCBI GeneID: 2491
• UniProt Accession #: Q92674; Q5JWZ9; Q96ED0
• Molecular Weight: 59,813 Da
• NCBI Official Full Name: Centromere protein I
• NCBI Official Synonym Full Names: centromere protein I
• NCBI Official Symbol: CENPI
• NCBI Official Synonym Symbols: LRPR1; CENP-I; FSHPRH1
• NCBI Protein Information: centromere protein I
• UniProt Protein Name: Centromere protein I
• Protein Family: Centromere protein
• UniProt Gene Name: CENPI
• UniProt Synonym Gene Names: FSHPRH1; ICEN19; LRPR1; CENP-I
• UniProt Entry Name: CENPI_HUMAN

NCBI Description

This gene encodes a centromere protein that is a component of the CENPA-NAC (nucleosome-associated) complex. This complex is critical for accurate chromosome alignment and segregation and it ensures proper mitotic progression. This protein regulates the recruitment of kinetochore-associated proteins that are required to generate the spindle checkpoint signal. The product of this gene is involved in the response of gonadal tissues to follicle-stimulating hormone. Mutations in this gene may be involved in human X-linked disorders of gonadal development and gametogenesis. Alternate splicing results in multiple transcript variants. A pseudogene of this gene is found on chromosome 13. [provided by RefSeq, Jan 2016]

Uniprot Description

CENPI: involved in the response of gonadal tissues to follicle-stimulating hormone. Highly expressed in testis, ovary and spleen.

Protein type: Unknown function

Chromosomal Location of Human Ortholog: Xq22.1

Cellular Component: cytoplasm; cytosol; kinetochore; nucleoplasm; nucleus

Molecular Function: protein binding

Biological Process: DNA replication-independent nucleosome assembly at centromere; sex differentiation; sister chromatid cohesion