SELENBP1 blocking peptide

SELENBP1 Antibody (C-term) Blocking Peptide

• Gene Names: SELENBP1; LPSB; SP56; hSBP; SBP56; HEL-S-134P
• Synonyms: SELENBP1; SELENBP1 Antibody (C-term) Blocking Peptide; Selenium-binding protein 1; 56 kDa selenium-binding protein; SBP56; SP56; SBP; SELENBP1 blocking peptide

• Specificity: The synthetic peptide sequence used to generate the antibody was selected from the C-term region of human SELENBP1. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
• Form/Format: Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
• Sequence Length: 472

• Cellular Location: Nucleus. Cytoplasm, cytosol. Membrane; Peripheral membrane protein. Note: May associate with Golgi membrane. May associate with the membrane of autophagosomes (By similarity).
• Tissue Location: Highly expressed in liver, lung, colon, prostate, kidney and pancreas. In brain, present both in neurons and glia (at protein level). Down-regulated in lung adenocarcinoma, colorectal carcinoma and ovarian cancer. Two-fold up-regulated in brain and blood from schizophrenia patients
• Preparation and Storage: Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.

Related Product Information for SELENBP1 blocking peptide

Selenium-binding protein which may be involved in the sensing of reactive xenobiotics in the cytoplasm. May be involved in intra-Golgi protein transport (By similarity).

NCBI and Uniprot Product Information

• NCBI GI #: 16306550
• NCBI GeneID: 8991
• NCBI Accession #: NP_003935
• NCBI GenBank Nucleotide #: NM_003944.3
• UniProt Accession #: Q13228; Q49AQ8; Q96GX7; A6NML9; A6PVW9; B2RDR3; B4DKP6; B4E1F3
• Molecular Weight: 56,866 Da
• NCBI Official Full Name: selenium-binding protein 1 isoform 1
• NCBI Official Synonym Full Names: selenium binding protein 1
• NCBI Official Symbol: SELENBP1
• NCBI Official Synonym Symbols: LPSB; SP56; hSBP; SBP56; HEL-S-134P
• NCBI Protein Information: selenium-binding protein 1
• UniProt Protein Name: Selenium-binding protein 1
• Protein Family: Selenium-binding protein
• UniProt Gene Name: SELENBP1
• UniProt Synonym Gene Names: SBP; SBP56; SP56
• UniProt Entry Name: SBP1_HUMAN

NCBI Description

This gene encodes a member of the selenium-binding protein family. Selenium is an essential nutrient that exhibits potent anticarcinogenic properties, and deficiency of selenium may cause certain neurologic diseases. The effects of selenium in preventing cancer and neurologic diseases may be mediated by selenium-binding proteins, and decreased expression of this gene may be associated with several types of cancer. The encoded protein may play a selenium-dependent role in ubiquitination/deubiquitination-mediated protein degradation. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Apr 2012]

Uniprot Description

SELENBP1: Selenium-binding protein which may be involved in the sensing of reactive xenobiotics in the cytoplasm. May be involved in intra-Golgi protein transport. Belongs to the selenium-binding protein family. 2 isoforms of the human protein are produced by alternative splicing.

Chromosomal Location of Human Ortholog: 1q21.3

Cellular Component: extracellular space; nucleolus

Molecular Function: protein binding