IGFALS blocking peptide

IGFALS Antibody (Center) Blocking Peptide

• Gene Names: IGFALS; ALS; ACLSD
• Synonyms: IGFALS; IGFALS Antibody (Center) Blocking Peptide; Insulin-like growth factor-binding protein complex acid labile subunit; ALS; IGFALS blocking peptide

• Specificity: The synthetic peptide sequence used to generate the antibody was selected from the Center region of human IGFALS. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
• Form/Format: Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
• Sequence Length: 605

• Cellular Location: Secreted, extracellular space.
• Tissue Location: Plasma.
• Preparation and Storage: Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.

Related Product Information for IGFALS blocking peptide

Involved in protein-protein interactions that result in protein complexes, receptor-ligand binding or cell adhesion.

NCBI and Uniprot Product Information

• NCBI GI #: 543800
• NCBI GeneID: 3483
• UniProt Accession #: P35858; B4DZY8; E9PGU3
• Molecular Weight: 70,236 Da
• NCBI Official Full Name: Insulin-like growth factor-binding protein complex acid labile subunit
• NCBI Official Synonym Full Names: insulin like growth factor binding protein acid labile subunit
• NCBI Official Symbol: IGFALS
• NCBI Official Synonym Symbols: ALS; ACLSD
• NCBI Protein Information: insulin-like growth factor-binding protein complex acid labile subunit
• UniProt Protein Name: Insulin-like growth factor-binding protein complex acid labile subunit
• Protein Family: Insulin-like growth factor-binding protein complex acid labile
• UniProt Gene Name: IGFALS
• UniProt Synonym Gene Names: ALS; ALS
• UniProt Entry Name: ALS_HUMAN

NCBI Description

The protein encoded by this gene is a serum protein that binds insulin-like growth factors, increasing their half-life and their vascular localization. Production of the encoded protein, which contains twenty leucine-rich repeats, is stimulated by growth hormone. Defects in this gene are a cause of acid-labile subunit deficiency, which maifests itself in a delayed and slow puberty. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Mar 2009]

Uniprot Description

IGFALS: Involved in protein-protein interactions that result in protein complexes, receptor-ligand binding or cell adhesion.

Protein type: Secreted; Secreted, signal peptide; Cell adhesion

Chromosomal Location of Human Ortholog: 16p13.3

Cellular Component: extracellular region; extracellular space; nucleoplasm

Molecular Function: insulin-like growth factor binding

Biological Process: cellular protein metabolic process; signal transduction

Disease: Acid-labile Subunit Deficiency