SNRPD2 blocking peptide

SNRPD2 Antibody (N-term) Blocking Peptide

• Gene Names: SNRPD2; SMD2; Sm-D2; SNRPD1
• Synonyms: SNRPD2; SNRPD2 Antibody (N-term) Blocking Peptide; Small nuclear ribonucleoprotein Sm D2; Sm-D2; snRNP core protein D2; SNRPD1; SNRPD2 blocking peptide

• Specificity: The synthetic peptide sequence used to generate the antibody was selected from the N-term region of human SNRPD2. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
• Form/Format: Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
• Sequence Length: 118

• Cellular Location: Cytoplasm, cytosol. Nucleus. Note: SMN-mediated assembly into core snRNPs occurs in the cytosol before SMN-mediated transport to the nucleus to be included in spliceosomes
• Preparation and Storage: Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.

Related Product Information for SNRPD2 blocking peptide

Core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Thereby, plays an important role in the splicing of cellular pre-mRNAs. Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in an heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP.

NCBI and Uniprot Product Information

• NCBI GI #: 51338666
• NCBI GeneID: 6633
• UniProt Accession #: P62316; P43330; A8K797; J3KPM5
• Molecular Weight: 12,399 Da
• NCBI Official Full Name: Small nuclear ribonucleoprotein Sm D2
• NCBI Official Synonym Full Names: small nuclear ribonucleoprotein D2 polypeptide
• NCBI Official Symbol: SNRPD2
• NCBI Official Synonym Symbols: SMD2; Sm-D2; SNRPD1
• NCBI Protein Information: small nuclear ribonucleoprotein Sm D2
• UniProt Protein Name: Small nuclear ribonucleoprotein Sm D2
• Protein Family: Probable small nuclear ribonucleoprotein
• UniProt Gene Name: SNRPD2
• UniProt Synonym Gene Names: SNRPD1; Sm-D2
• UniProt Entry Name: SMD2_HUMAN

NCBI Description

The protein encoded by this gene belongs to the small nuclear ribonucleoprotein core protein family. It is required for pre-mRNA splicing and small nuclear ribonucleoprotein biogenesis. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2009]

Uniprot Description

snRNP D2: Required for pre-mRNA splicing. Required for snRNP biogenesis. Belongs to the snRNP core protein family.

Protein type: Spliceosome; RNA splicing

Chromosomal Location of Human Ortholog: 19q13.2

Cellular Component: cytosol; nucleoplasm; small nuclear ribonucleoprotein complex; snRNP U1; snRNP U2; snRNP U5; spliceosome; U12-dependent spliceosome; U4/U6 x U5 tri-snRNP complex

Molecular Function: protein binding

Biological Process: nuclear import; nuclear mRNA splicing, via spliceosome; RNA splicing; spliceosomal snRNP biogenesis; spliceosome assembly