MMP16 blocking peptide

MMP16 Antibody (N-term) Blocking Peptide

• Gene Names: MMP16; MMP-X2; C8orf57; MT-MMP2; MT-MMP3; MT3-MMP
• Synonyms: MMP16; MMP16 Antibody (N-term) Blocking Peptide; Matrix metalloproteinase-16; MMP-16; 3424-; MMP-X2; Membrane-type matrix metalloproteinase 3; MT-MMP 3; MTMMP3; Membrane-type-3 matrix metalloproteinase; MT3-MMP; MT3MMP; MMPX2; MMP16 blocking peptide

• Specificity: The synthetic peptide sequence used to generate the antibody was selected from the N-term region of human MMP16. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
• Form/Format: The synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml deionized water for a final concentration of 1 mg/ml.
• Sequence Length: 457

• Cellular Location: Isoform Long: Cell membrane; Single-pass type I membrane protein; Extracellular side. Note: Localized at the cell surface of melanoma cells
• Tissue Location: Expressed in heart, brain, placenta, ovary and small intestine. Isoform Short is found in the ovary
• Preparation and Storage: Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.

Related Product Information for MMP16 blocking peptide

Endopeptidase that degrades various components of the extracellular matrix, such as collagen type III and fibronectin. Activates progelatinase A. Involved in the matrix remodeling of blood vessels. Isoform short cleaves fibronectin and also collagen type III, but at lower rate. It has no effect on type I, II, IV and V collagen. However, upon interaction with CSPG4, it may be involved in degradation and invasion of type I collagen by melanoma cells.

NCBI and Uniprot Product Information

• NCBI GI #: 149999365
• NCBI GeneID: 4325
• NCBI Accession #: NP_072086
• NCBI GenBank Nucleotide #: NM_022564.3
• UniProt Accession #: P51512; Q14824; Q52H48; B2RAN7
• Molecular Weight: 52,515 Da
• NCBI Official Synonym Full Names: matrix metallopeptidase 16
• NCBI Official Symbol: MMP16
• NCBI Official Synonym Symbols: MMP-X2; C8orf57; MT-MMP2; MT-MMP3; MT3-MMP
• NCBI Protein Information: matrix metalloproteinase-16
• UniProt Protein Name: Matrix metalloproteinase-16
• Protein Family: Matrix metalloproteinase
• UniProt Gene Name: MMP16
• UniProt Synonym Gene Names: MMPX2; MMP-16; MT-MMP 3; MTMMP3; MT3-MMP; MT3MMP
• UniProt Entry Name: MMP16_HUMAN

NCBI Description

Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. The encoded protein activates MMP2 by cleavage. This gene was once referred to as MT-MMP2, but was renamed as MT-MMP3 or MMP16. [provided by RefSeq, Oct 2010]

Uniprot Description

MMP16: Endopeptidase that degrades various components of the extracellular matrix, such as collagen type III and fibronectin. Activates progelatinase A. Involved in the matrix remodeling of blood vessels. Isoform short cleaves fibronectin and also collagen type III, but at lower rate. It has no effect on type I, II, IV and V collagen. However, upon interaction with CSPG4, it may be involved in degradation and invasion of type I collagen by melanoma cells. Belongs to the peptidase M10A family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral; EC 3.4.24.-; Protease

Chromosomal Location of Human Ortholog: 8q21.3

Cellular Component: Golgi lumen; integral to plasma membrane; plasma membrane

Molecular Function: enzyme activator activity

Biological Process: extracellular matrix disassembly