GCH1 blocking peptide

GCH1 Antibody (N-term) Blocking peptide

• Gene Names: GCH1; GCH; DYT5; DYT14; DYT5a; GTPCH1; HPABH4B; GTP-CH-1
• Synonyms: GCH1; GCH1 Antibody (N-term) Blocking peptide; GTP cyclohydrolase 1; GTP cyclohydrolase I; GTP-CH-I; DYT5; GCH; GCH1 blocking peptide

• Form/Format: Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
• Sequence Length: 250

• Cellular Location: Cytoplasm. Nucleus.
• Tissue Location: In epidermis, expressed predominantly in basal undifferentiated keratinocytes and in some but not all melanocytes (at protein level).
• Preparation and Storage: Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.

Related Product Information for GCH1 blocking peptide

Positively regulates nitric oxide synthesis in umbilical vein endothelial cells (HUVECs). May be involved in dopamine synthesis. May modify pain sensitivity and persistence. Isoform GCH-1 is the functional enzyme, the potential function of the enzymatically inactive isoforms remains unknown.

NCBI and Uniprot Product Information

• NCBI GI #: 4503949
• NCBI GeneID: 2643
• NCBI Accession #: NP_000152.1
• NCBI GenBank Nucleotide #: NM_000161.2
• UniProt Accession #: P30793; Q6FHY7; Q9Y4I8
• Molecular Weight: 25,775 Da
• NCBI Official Full Name: GTP cyclohydrolase 1 isoform 1
• NCBI Official Synonym Full Names: GTP cyclohydrolase 1
• NCBI Official Symbol: GCH1
• NCBI Official Synonym Symbols: GCH; DYT5; DYT14; DYT5a; GTPCH1; HPABH4B; GTP-CH-1
• NCBI Protein Information: GTP cyclohydrolase 1
• UniProt Protein Name: GTP cyclohydrolase 1
• Protein Family: GTP cyclohydrolase
• UniProt Gene Name: GCH1
• UniProt Synonym Gene Names: DYT5; GCH; GTP-CH-I
• UniProt Entry Name: GCH1_HUMAN

NCBI Description

This gene encodes a member of the GTP cyclohydrolase family. The encoded protein is the first and rate-limiting enzyme in tetrahydrobiopterin (BH4) biosynthesis, catalyzing the conversion of GTP into 7,8-dihydroneopterin triphosphate. BH4 is an essential cofactor required by aromatic amino acid hydroxylases as well as nitric oxide synthases. Mutations in this gene are associated with malignant hyperphenylalaninemia and dopa-responsive dystonia. Several alternatively spliced transcript variants encoding different isoforms have been described; however, not all variants give rise to a functional enzyme. [provided by RefSeq, Jul 2008]

Uniprot Description

Positively regulates nitric oxide synthesis in umbilical vein endothelial cells (HUVECs). May be involved in dopamine synthesis. May modify pain sensitivity and persistence. Isoform GCH-1 is the functional enzyme, the potential function of the enzymatically inactive isoforms remains unknown.