BIN2 blocking peptide
BIN2 Antibody (N-term) Blocking peptide
Gene Names
BIN2; BRAP-1
Synonyms
BIN2; BIN2 Antibody (N-term) Blocking peptide; Bridging integrator 2; Breast cancer-associated protein 1; BRAP1; BIN2 blocking peptide
Form/Format
Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
Sequence Length
565
Cellular Location
Cytoplasm. Cell projection, podosome membrane; Peripheral membrane protein; Cytoplasmic side Cytoplasm, cell cortex. Cell projection, phagocytic cup Note: Associates with membranes enriched in phosphoinositides Detected in the actin-rich cell cortex at the leading edge of migrating cells. Detected at podosomes, at an actin-rich ring-like structure
Tissue Location
Detected in natural killer cells (at protein level). Highest level expression seen in spleen and peripheral blood leukocytes and is also expressed at high levels in thymus, colon and placenta, suggesting preferential expression in hematopoietic tissues.
Preparation and Storage
Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.
Related Product Information for BIN2 blocking peptide
Promotes cell motility and migration, probably via its interaction with the cell membrane and with podosome proteins that mediate interaction with the cytoskeleton. Modulates membrane curvature and mediates membrane tubulation. Plays a role in podosome formation. Inhibits phagocytosis.
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
58,030 Da
NCBI Official Full Name
bridging integrator 2
NCBI Official Synonym Full Names
bridging integrator 2
NCBI Official Symbol
BIN2
NCBI Official Synonym Symbols
BRAP-1
NCBI Protein Information
bridging integrator 2
UniProt Protein Name
Bridging integrator 2
Protein Family
UniProt Gene Name
BIN2
UniProt Synonym Gene Names
BRAP1
UniProt Entry Name
BIN2_HUMAN
Uniprot Description
BIN2: 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Adaptor/scaffold
Chromosomal Location of Human Ortholog: 12q13
Cellular Component: phagocytic cup; podosome
Molecular Function: phospholipid binding; protein binding
Biological Process: phagocytosis, engulfment
Research Articles on BIN2
Similar Products
Product Notes
The BIN2 bin2 (Catalog #AAA9225780) is a Blocking Peptide and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "BIN2, Blocking Peptide" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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