PIN4 blocking peptide
PIN4 Antibody (N-term) Blocking Peptide
Gene Names
PIN4; EPVH; PAR14; PAR17
Synonyms
PIN4; PIN4 Antibody (N-term) Blocking Peptide; Peptidyl-prolyl cis-trans isomerase NIMA-interacting 4; Parvulin-14; Par14; hPar14; Parvulin-17; Par17; hPar17; Peptidyl-prolyl cis-trans isomerase Pin4; PPIase Pin4; Peptidyl-prolyl cis/trans isomerase EPVH; hEPVH; Rotamase Pin4; PIN4 blocking peptide
Form/Format
Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
Sequence Length
131
Cellular Location
Isoform 1: Nucleus, nucleolus. Cytoplasm, cytoskeleton, spindle. Cytoplasm. Note: Colocalizes in the nucleolus during interphase and on the spindle apparatus during mitosis with NPM1
Tissue Location
Isoform 2 is much more stable than isoform 1 (at protein level). Ubiquitous. Isoform 1 and isoform 2 are expressed in kidney, liver, blood vessel, brain, mammary gland, skeletal muscle, small intestine and submandibularis. Isoform 1 transcripts are much more abundant than isoform 2 in each tissue analyzed.
Preparation and Storage
Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.
Related Product Information for PIN4 blocking peptide
Isoform 1 is involved as a ribosomal RNA processing factor in ribosome biogenesis. Binds to tightly bent AT-rich stretches of double-stranded DNA.
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
Molecular Weight
14,179 Da
NCBI Official Full Name
Peptidyl-prolyl cis-trans isomerase NIMA-interacting 4
NCBI Official Synonym Full Names
peptidylprolyl cis/trans isomerase, NIMA-interacting 4
NCBI Official Symbol
PIN4
NCBI Official Synonym Symbols
EPVH; PAR14; PAR17
NCBI Protein Information
peptidyl-prolyl cis-trans isomerase NIMA-interacting 4
UniProt Protein Name
Peptidyl-prolyl cis-trans isomerase NIMA-interacting 4
Protein Family
UniProt Gene Name
PIN4
UniProt Synonym Gene Names
Par14; hPar14; Par17; hPar17; PPIase Pin4; hEPVH
UniProt Entry Name
PIN4_HUMAN
NCBI Description
This gene encodes a member of the parvulin subfamily of the peptidyl-prolyl cis/trans isomerase protein family. The encoded protein catalyzes the isomerization of peptidylprolyl bonds, and may play a role in the cell cycle, chromatin remodeling, and/or ribosome biogenesis. The encoded protein may play an additional role in the mitochondria. [provided by RefSeq, Dec 2009]
Uniprot Description
PIN4: Isoform 1 is involved as a ribosomal RNA processing factor in ribosome biogenesis. Binds to tightly bent AT-rich stretches of double-stranded DNA. Belongs to the PpiC/parvulin rotamase family. PIN4 subfamily. 2 isoforms of the human protein are produced by alternative promoter.
Protein type: Nucleolus; Isomerase; Mitochondrial; EC 5.2.1.8
Chromosomal Location of Human Ortholog: Xq13
Molecular Function: protein binding
