CLC blocking peptide

CLC Antibody (C-term) Blocking Peptide

• Gene Names: CLC; GAL10; Gal-10; LGALS10; LGALS10A; LPPL_HUMAN
• Synonyms: CLC; CLC Antibody (C-term) Blocking Peptide; Galectin-10; Gal-10; Charcot-Leyden crystal protein; Eosinophil lysophospholipase; Lysolecithin acylhydrolase; LGALS10; LGALS10A; CLC blocking peptide

• Form/Format: Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
• Sequence Length: 142

• Cellular Location: Cytoplasm, cytosol. Cytoplasmic granule. Note: Localized in granules from where it may be secreted or transported to other locations in the cell
• Tissue Location: Expressed abundantly in the bone marrow. Expressed exclusively by eosinophils and basophils. Not detected in monocytes and neutrophils. Expressed in CD25-positive regulatory T-cells (Treg) (at protein level). Found in intestinal tissue from patients with Celiac disease, expression is directly related to the histological grade of mucosal damage and to the number of eosinophils found in the duodenal lesion (at protein level). Found in sputum of patients with eosinophilic inflammatory diseases such as asthma (at protein level)
• Preparation and Storage: Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.

Related Product Information for CLC blocking peptide

Regulates immune responses through the recognition of cell-surface glycans. Essential for the anergy and suppressive function of CD25-positive regulatory T-cells (Treg).

NCBI and Uniprot Product Information

• NCBI GI #: 317373429
• NCBI GeneID: 1178
• UniProt Accession #: Q05315; Q0VDE3; C5HZ13; C5HZ14
• Molecular Weight: 16,453 Da
• NCBI Official Full Name: Galectin-10
• NCBI Official Synonym Full Names: Charcot-Leyden crystal galectin
• NCBI Official Symbol: CLC
• NCBI Official Synonym Symbols: GAL10; Gal-10; LGALS10; LGALS10A; LPPL_HUMAN
• NCBI Protein Information: galectin-10
• UniProt Protein Name: Galectin-10
• Protein Family: Clathrin
• UniProt Gene Name: CLC
• UniProt Synonym Gene Names: LGALS10; LGALS10A; Gal-10; CLC
• UniProt Entry Name: LEG10_HUMAN

NCBI Description

Lysophospholipases are enzymes that act on biological membranes to regulate the multifunctional lysophospholipids. The protein encoded by this gene is a lysophospholipase expressed in eosinophils and basophils. It hydrolyzes lysophosphatidylcholine to glycerophosphocholine and a free fatty acid. This protein may possess carbohydrate or IgE-binding activities. It is both structurally and functionally related to the galectin family of beta-galactoside binding proteins. It may be associated with inflammation and some myeloid leukemias. [provided by RefSeq, Jul 2008]

Uniprot Description

Regulates immune responses through the recognition of cell-surface glycans. Essential for the anergy and suppressive function of CD25-positive regulatory T-cells (Treg).