GCAP1 Blocking Peptide | GUCA1A blocking peptide

GCAP1 Antibody (C-term) Blocking Peptide

• Gene Names: GUCA1A; COD3; GCAP; GUCA; GCAP1; GUCA1; CORD14; C6orf131
• Synonyms: GCAP1; GCAP1 Antibody (C-term) Blocking Peptide; Guanylyl cyclase-activating protein 1; GCAP 1; Guanylate cyclase activator 1A; GUCA1A; C6orf131; GCAP; GUCA1; GUCA1A blocking peptide

• Specificity: The synthetic peptide sequence used to generate the antibody was selected from the C-term region of human GCAP1. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
• Form/Format: The synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml deionized water for a final concentration of 1 mg/ml.
• Sequence Length: 201

• Cellular Location: Membrane; Lipid-anchor.
• Tissue Location: Retina; cone outer and inner segments, in particular, in disk membrane regions, and to a lesser extent rod inner and outer segments
• Preparation and Storage: Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.

Related Product Information for GUCA1A blocking peptide

Stimulates guanylyl cyclase 1 (GC1) when free calcium ions concentration is low and inhibits GC1 when free calcium ions concentration is elevated. This Ca(2+)-sensitive regulation of GC is a key event in recovery of the dark state of rod photoreceptors following light exposure.

NCBI and Uniprot Product Information

• NCBI GI #: 46577585
• NCBI GeneID: 2978
• UniProt Accession #: P43080; Q7Z6T1; Q9NU14; B3KWT4
• Molecular Weight: 22,920 Da
• NCBI Official Full Name: Guanylyl cyclase-activating protein 1
• NCBI Official Synonym Full Names: guanylate cyclase activator 1A
• NCBI Official Symbol: GUCA1A
• NCBI Official Synonym Symbols: COD3; GCAP; GUCA; GCAP1; GUCA1; CORD14; C6orf131
• NCBI Protein Information: guanylyl cyclase-activating protein 1
• UniProt Protein Name: Guanylyl cyclase-activating protein 1
• Protein Family: Guanylyl cyclase-activating protein
• UniProt Gene Name: GUCA1A
• UniProt Synonym Gene Names: C6orf131; GCAP; GCAP1; GUCA1; GCAP 1
• UniProt Entry Name: GUC1A_HUMAN

NCBI Description

This gene encodes an enzyme that plays a role in the recovery of retinal photoreceptors from photobleaching. This enzyme promotes the activity of retinal guanylyl cyclase-1 (GC1) at low calcium concentrations and inhibits GC1 at high calcium concentrations. Mutations in this gene can cause cone dystrophy 3 and code-rod dystrophy 14. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2016]

Uniprot Description

GUCA1A: Stimulates guanylyl cyclase 1 (GC1) when free calcium ions concentration is low and inhibits GC1 when free calcium ions concentration is elevated. This Ca(2+)-sensitive regulation of GC is a key event in recovery of the dark state of rod photoreceptors following light exposure. Defects in GUCA1A are the cause of cone dystrophy type 3 (COD3). COD3 is an autosomal dominant cone dystrophy. Cone dystrophies are retinal dystrophies characterized by progressive degeneration of the cone photoreceptors with preservation of rod function, as indicated by electroretinogram. However, some rod involvement may be present in some cone dystrophies, particularly at late stage. Affected individuals suffer from photophobia, loss of visual acuity, color vision and central visual field. Another sign is the absence of macular lesions for many years. Cone dystrophies are distinguished from the cone-rod dystrophies, in which some loss of peripheral vision also occurs.

Chromosomal Location of Human Ortholog: 6p21.1

Cellular Component: plasma membrane

Molecular Function: calcium ion binding; calcium sensitive guanylate cyclase activator activity; guanylate cyclase regulator activity

Biological Process: positive regulation of guanylate cyclase activity; regulation of rhodopsin mediated signaling

Disease: Cone Dystrophy 3