NDN blocking peptide

NDN Antibody (N-term) Blocking Peptide

• Gene Names: NDN; PWCR; HsT16328
• Synonyms: NDN; NDN Antibody (N-term) Blocking Peptide; Necdin; NDN blocking peptide

• Form/Format: Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
• Sequence Length: 321

• Cellular Location: Perikaryon. Nucleus. Note: Neural perikarya, translocates to the nucleus of postmitotic neurons and interacts with the nuclear matrix
• Tissue Location: Almost ubiquitous. Detected in fetal brain, lung, liver and kidney; in adult heart, brain, placenta, lung, liver, skeletal muscle, kidney, pancreas, spleen, thymus, prostate, testis, ovary, small intestine and colon. Not detected in peripheral blood leukocytes. In brain, restricted to post- mitotic neurons
• Preparation and Storage: Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.

Related Product Information for NDN blocking peptide

Growth suppressor that facilitates the entry of the cell into cell cycle arrest. Functionally similar to the retinoblastoma protein it binds to and represses the activity of cell-cycle- promoting proteins such as SV40 large T antigen, adenovirus E1A, and the transcription factor E2F. Necdin also interacts with p53 and works in an additive manner to inhibit cell growth. Functions also as transcription factor and binds directly to specific guanosine-rich DNA sequences (By similarity).

NCBI and Uniprot Product Information

• NCBI GI #: 17380142
• NCBI GeneID: 4692
• UniProt Accession #: Q99608; B2R6Z5
• Molecular Weight: 36,086 Da
• NCBI Official Full Name: Necdin
• NCBI Official Synonym Full Names: necdin, MAGE family member
• NCBI Official Symbol: NDN
• NCBI Official Synonym Symbols: PWCR; HsT16328
• NCBI Protein Information: necdin
• UniProt Protein Name: Necdin
• Protein Family: Necdin
• UniProt Gene Name: NDN
• UniProt Entry Name: NECD_HUMAN

NCBI Description

This intronless gene is located in the Prader-Willi syndrome deletion region. It is an imprinted gene and is expressed exclusively from the paternal allele. Studies in mouse suggest that the protein encoded by this gene may suppress growth in postmitotic neurons. [provided by RefSeq, Jul 2008]

Uniprot Description

NDN: Growth suppressor that facilitates the entry of the cell into cell cycle arrest. Functionally similar to the retinoblastoma protein it binds to and represses the activity of cell-cycle- promoting proteins such as SV40 large T antigen, adenovirus E1A, and the transcription factor E2F. Necdin also interacts with p53 and works in an additive manner to inhibit cell growth. Functions also as transcription factor and binds directly to specific guanosine-rich DNA sequences.

Protein type: Transcription factor; DNA-binding

Chromosomal Location of Human Ortholog: 15q11.2-q12

Biological Process: nervous system development

Disease: Prader-willi Syndrome