MLL5 Blocking Peptide | KMT2E blocking peptide

MLL5 Antibody (N-term) Blocking Peptide

• Gene Names: KMT2E; MLL5; NKp44L; HDCMC04P
• Synonyms: MLL5; MLL5 Antibody (N-term) Blocking Peptide; Histone-lysine N-methyltransferase 2E; Lysine N-methyltransferase 2E; Myeloid/lymphoid or mixed-lineage leukemia protein 5; KMT2E; KMT2E blocking peptide

• Form/Format: Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
• Sequence Length: 1858

• Cellular Location: Nucleus speckle. Note: Absent from the nucleolus
• Tissue Location: Widely expressed in both adult and fetal tissues. Highest levels of expression observed in fetal thymus and kidney and in adult hematopoietic tissues, jejunum and cerebellum Isoform NKp44L is not detected on circulating cells from healthy individuals, but it is expressed on a large panel of the tumor and transformed cells.
• Preparation and Storage: Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.

Related Product Information for KMT2E blocking peptide

Histone methyltransferase that specifically mono- and dimethylates 'Lys-4' of histone H3 (H3K4me1 and H3K4me2). H3 'Lys- 4' methylation represents a specific tag for epigenetic transcriptional activation. Key regulator of hematopoiesis involved in terminal myeloid differentiation and in the regulation of hematopoietic stem cell (HSCs) self-renewal by a mechanism that involves DNA methylation. Plays an essential role in retinoic- acid-induced granulopoiesis by acting as a coactivator of RAR- alpha (RARA) in target gene promoters. Also acts as an important cell cycle regulator, participating in cell cycle regulatory network machinery at multiple cell cycle stages. Required to suppress inappropriate expression of S-phase-promoting genes and maintain expression of determination genes in quiescent cells. Overexpression inhibits cell cycle progression, while knockdown induces cell cycle arrest at both the G1 and G2/M phases.

NCBI and Uniprot Product Information

• NCBI GI #: 74723669
• NCBI GeneID: 55904
• UniProt Accession #: Q8IZD2; Q6P5Y2; Q6PKG4; Q6T316; Q86TI3; Q86W12; Q86WG0; Q86WL2; Q8IV78; B6ZDE4; B6ZDM3; M4K8J3
• Molecular Weight: 131,737 Da
• NCBI Official Full Name: Histone-lysine N-methyltransferase 2E
• NCBI Official Synonym Full Names: lysine methyltransferase 2E
• NCBI Official Symbol: KMT2E
• NCBI Official Synonym Symbols: MLL5; NKp44L; HDCMC04P
• NCBI Protein Information: histone-lysine N-methyltransferase 2E
• UniProt Protein Name: Histone-lysine N-methyltransferase 2E
• Protein Family: Histone-lysine N-methyltransferase
• UniProt Gene Name: KMT2E
• UniProt Synonym Gene Names: MLL5; Lysine N-methyltransferase 2E
• UniProt Entry Name: KMT2E_HUMAN

NCBI Description

This gene is a member of the myeloid/lymphoid or mixed-lineage leukemia (MLL) family and encodes a protein with an N-terminal PHD zinc finger and a central SET domain. Overexpression of the protein inhibits cell cycle progression. Alternate transcriptional splice variants have been characterized. [provided by RefSeq, Jul 2008]

Uniprot Description

MLL5: Histone methyltransferase that specifically mono- and dimethylates 'Lys-4' of histone H3 (H3K4me1 and H3K4me2). H3 'Lys- 4' methylation represents a specific tag for epigenetic transcriptional activation. Key regulator of hematopoiesis involved in terminal myeloid differentiation and in the regulation of hematopoietic stem cell (HSCs) self-renewal by a mechanism that involves DNA methylation. Plays an essential role in retinoic- acid-induced granulopoiesis by acting as a coactivator of RAR- alpha (RARA) in target gene promoters. Also acts as an important cell cycle regulator, participating in cell cycle regulatory network machinery at multiple cell cycle stages. Required to suppress inappropriate expression of S-phase-promoting genes and maintain expression of determination genes in quiescent cells. Overexpression inhibits cell cycle progression, while knockdown induces cell cycle arrest at both the G1 and G2/M phases. Belongs to the histone-lysine methyltransferase family. TRX/MLL subfamily. 7 isoforms of the human protein are produced by alternative splicing.

Protein type: Methyltransferase; EC 2.1.1.43; Cell cycle regulation; Methyltransferase, protein lysine; Transcription, coactivator/corepressor

Chromosomal Location of Human Ortholog: 7q22.1

Cellular Component: intercellular bridge; intracellular membrane-bound organelle; nucleoplasm

Molecular Function: enzyme binding; histone lysine N-methyltransferase activity (H3-K4 specific); histone-lysine N-methyltransferase activity; protein binding; transcription coactivator activity

Biological Process: DNA methylation; erythrocyte differentiation; histone H3-K4 methylation; neutrophil activation; neutrophil mediated immunity; positive regulation of granulocyte differentiation; positive regulation of transcription, DNA-dependent; retinoic acid receptor signaling pathway