FCGR2B blocking peptide

FCGR2B Antibody (C-term) Blocking peptide

• Gene Names: FCGR2B; CD32; FCG2; CD32B; FCGR2; IGFR2
• Synonyms: FCGR2B; FCGR2B Antibody (C-term) Blocking peptide; Low affinity immunoglobulin gamma Fc region receptor II-b; IgG Fc receptor II-b; CDw32; Fc-gamma RII-b; Fc-gamma-RIIb; FcRII-b; CD32; FCG2; IGFR2; FCGR2B blocking peptide

• Specificity: The synthetic peptide sequence used to generate the antibody was selected from the C-term region of FCGR2B. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
• Form/Format: Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
• Sequence Length: 310

• Cellular Location: Cell membrane; Single-pass type I membrane protein
• Tissue Location: Is the most broadly distributed Fc-gamma- receptor. Expressed in monocyte, neutrophils, macrophages, basophils, eosinophils, Langerhans cells, B-cells, platelets cells and placenta (endothelial cells). Not detected in natural killer cells
• Preparation and Storage: Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.

Related Product Information for FCGR2B blocking peptide

Receptor for the Fc region of complexed or aggregated immunoglobulins gamma. Low affinity receptor. Involved in a variety of effector and regulatory functions such as phagocytosis of immune complexes and modulation of antibody production by B- cells. Binding to this receptor results in down-modulation of previous state of cell activation triggered via antigen receptors on B-cells (BCR), T-cells (TCR) or via another Fc receptor. Isoform IIB1 fails to mediate endocytosis or phagocytosis. Isoform IIB2 does not trigger phagocytosis.

NCBI and Uniprot Product Information

• NCBI GI #: 8039788
• NCBI GeneID: 2213
• UniProt Accession #: P31994; O95649; Q53X85; Q5VXA9; Q8NIA1; A6H8N3
• Molecular Weight: 33,450 Da
• NCBI Official Full Name: Low affinity immunoglobulin gamma Fc region receptor II-b
• NCBI Official Synonym Full Names: Fc fragment of IgG receptor IIb
• NCBI Official Symbol: FCGR2B
• NCBI Official Synonym Symbols: CD32; FCG2; CD32B; FCGR2; IGFR2
• NCBI Protein Information: low affinity immunoglobulin gamma Fc region receptor II-b
• UniProt Protein Name: Low affinity immunoglobulin gamma Fc region receptor II-b
• Protein Family: Low affinity immunoglobulin gamma Fc region receptor
• UniProt Gene Name: FCGR2B
• UniProt Synonym Gene Names: CD32; FCG2; IGFR2; IgG Fc receptor II-b; Fc-gamma-RIIb; FcRII-b
• UniProt Entry Name: FCG2B_HUMAN

NCBI Description

The protein encoded by this gene is a low affinity receptor for the Fc region of immunoglobulin gamma complexes. The encoded protein is involved in the phagocytosis of immune complexes and in the regulation of antibody production by B-cells. Variations in this gene may increase susceptibilty to systemic lupus erythematosus (SLE). Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2010]

Uniprot Description

Receptor for the Fc region of complexed or aggregated immunoglobulins gamma. Low affinity receptor. Involved in a variety of effector and regulatory functions such as phagocytosis of immune complexes and modulation of antibody production by B-cells. Binding to this receptor results in down-modulation of previous state of cell activation triggered via antigen receptors on B-cells (BCR), T-cells (TCR) or via another Fc receptor. Isoform IIB1 fails to mediate endocytosis or phagocytosis. Isoform IIB2 does not trigger phagocytosis.