VTI1B blocking peptide

VTI1B Antibody (Center) Blocking peptide

• Gene Names: VTI1B; VTI1; VTI2; VTI1L; v-SNARE; vti1-rp1; VTI1-LIKE
• Synonyms: VTI1B; VTI1B Antibody (Center) Blocking peptide; Vesicle transport through interaction with t-SNAREs homolog 1B; Vesicle transport v-SNARE protein Vti1-like 1; Vti1-rp1; VTI1; VTI1L; VTI1L1; VTI2; VTI1B blocking peptide

• Specificity: The synthetic peptide sequence used to generate the antibody was selected from the Center region of VTI1B. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
• Form/Format: Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
• Sequence Length: 232

• Cellular Location: Late endosome membrane; Single-pass type IV membrane protein. Lysosome membrane. Cytoplasmic granule
• Tissue Location: Expressed in all tissues examined.
• Preparation and Storage: Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.

Related Product Information for VTI1B blocking peptide

V-SNARE that mediates vesicle transport pathways through interactions with t-SNAREs on the target membrane. These interactions are proposed to mediate aspects of the specificity of vesicle trafficking and to promote fusion of the lipid bilayers. May be concerned with increased secretion of cytokines associated with cellular senescence.

NCBI and Uniprot Product Information

• NCBI GI #: 126302613
• NCBI GeneID: 10490
• UniProt Accession #: Q9UEU0; O43547; Q96J28
• Molecular Weight: 19,810 Da
• NCBI Official Full Name: Vesicle transport through interaction with t-SNAREs homolog 1B
• NCBI Official Synonym Full Names: vesicle transport through interaction with t-SNAREs 1B
• NCBI Official Symbol: VTI1B
• NCBI Official Synonym Symbols: VTI1; VTI2; VTI1L; v-SNARE; vti1-rp1; VTI1-LIKE
• NCBI Protein Information: vesicle transport through interaction with t-SNAREs homolog 1B
• UniProt Protein Name: Vesicle transport through interaction with t-SNAREs homolog 1B
• Protein Family: Vesicle transport through interaction with t-SNAREs
• UniProt Gene Name: VTI1B
• UniProt Synonym Gene Names: VTI1; VTI1L; VTI1L1; VTI2
• UniProt Entry Name: VTI1B_HUMAN

Uniprot Description

VTI1B: V-SNARE that mediates vesicle transport pathways through interactions with t-SNAREs on the target membrane. These interactions are proposed to mediate aspects of the specificity of vesicle trafficking and to promote fusion of the lipid bilayers. May be concerned with increased secretion of cytokines associated with cellular senescence. Belongs to the VTI1 family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Vesicle; Membrane protein, integral

Chromosomal Location of Human Ortholog: 14q24.1

Cellular Component: cell soma; cytoplasm; endoplasmic reticulum membrane; Golgi apparatus; intracellular membrane-bound organelle; late endosome membrane; lysosomal membrane; perinuclear region of cytoplasm; recycling endosome; SNARE complex; synaptic vesicle; vesicle

Molecular Function: chloride channel inhibitor activity; protein binding; SNAP receptor activity; SNARE binding

Biological Process: cell proliferation; ER to Golgi vesicle-mediated transport; Golgi to vacuole transport; intra-Golgi vesicle-mediated transport; protein targeting to vacuole; retrograde transport, endosome to Golgi; vesicle docking during exocytosis; vesicle fusion with Golgi apparatus; vesicle-mediated transport