GRM6 blocking peptide

GRM6 Antibody (Center) Blocking peptide

• Gene Names: GRM6; mGlu6; CSNB1B; GPRC1F; MGLUR6
• Synonyms: GRM6; GRM6 Antibody (Center) Blocking peptide; Metabotropic glutamate receptor 6; mGluR6; GPRC1F; MGLUR6; GRM6 blocking peptide

• Specificity: The synthetic peptide sequence used to generate the antibody was selected from the Center region of GRM6. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
• Form/Format: Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
• Sequence Length: 877

• Cellular Location: Cell membrane; Multi-pass membrane protein Endoplasmic reticulum membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein. Cell projection, dendrite. Note: Subject to trafficking from the endoplasmic reticulum to the Golgi apparatus and then to the cell membrane
• Tissue Location: Detected in melanocytes.
• Preparation and Storage: Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.

Related Product Information for GRM6 blocking peptide

G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity (By similarity). Signaling stimulates TRPM1 channel activity and Ca(2+) uptake. Required for normal vision.

NCBI and Uniprot Product Information

• NCBI GI #: 239938639
• NCBI GeneID: 2916
• UniProt Accession #: O15303
• Molecular Weight: 95,468 Da
• NCBI Official Full Name: Metabotropic glutamate receptor 6
• NCBI Official Synonym Full Names: glutamate metabotropic receptor 6
• NCBI Official Symbol: GRM6
• NCBI Official Synonym Symbols: mGlu6; CSNB1B; GPRC1F; MGLUR6
• NCBI Protein Information: metabotropic glutamate receptor 6
• UniProt Protein Name: Metabotropic glutamate receptor 6
• Protein Family: Metabotropic glutamate receptor
• UniProt Gene Name: GRM6
• UniProt Synonym Gene Names: GPRC1F; MGLUR6; mGluR6
• UniProt Entry Name: GRM6_HUMAN

NCBI Description

L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors, that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5 and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3 while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities. [provided by RefSeq, Feb 2012]

Uniprot Description

mGluR6: Receptor for glutamate. The activity of this receptor is mediated by a G-protein that inhibits adenylate cyclase activity. Defects in GRM6 are the cause of congenital stationary night blindness type 1B (CSNB1B). This disorder consits of a previously unrecognized, autosomal recessive form of congenital night blindness associated with a negative electroretinogram waveform. Patients are night blind from an early age, and when maximally dark-adapted, they could perceive lights only with an intensity equal to or slightly dimmer than that normally detected by the cone system. ERGs in response to single brief flashes of light have clearly detectable a-waves, which are derived from photoreceptors, and greatly reduced b-waves, which are derived from the second-order inner retinal neurons. ERGs in response to sawtooth flickering light indicate a markedly reduced ON response and a nearly normal OFF response. There is no subjective delay in the perception of suddenly appearing white vs black objects on a gray background. Belongs to the G-protein coupled receptor 3 family.

Protein type: Receptor, GPCR; Membrane protein, multi-pass; GPCR, family 3; Membrane protein, integral

Chromosomal Location of Human Ortholog: 5q35

Cellular Component: endoplasmic reticulum membrane; Golgi membrane; integral to plasma membrane; plasma membrane; presynaptic membrane

Molecular Function: G-protein coupled receptor activity; glutamate receptor activity; group III metabotropic glutamate receptor activity; protein binding; protein homodimerization activity

Biological Process: detection of light stimulus involved in visual perception; detection of visible light; metabotropic glutamate receptor signaling pathway; regulation of synaptic transmission, glutamatergic

Disease: Night Blindness, Congenital Stationary, Type 1b