SELK blocking peptide

SELK Antibody (Center) Blocking peptide

• Gene Names: SELK; SelK; HSPC030; HSPC297
• Synonyms: SELK; SELK Antibody (Center) Blocking peptide; Selenoprotein K; SelK; SELK blocking peptide

• Specificity: The synthetic peptide sequence used to generate the antibody was selected from the Center region of SELK. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
• Form/Format: Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
• Sequence Length: 94

• Cellular Location: Endoplasmic reticulum membrane; Single-pass membrane protein. Cell membrane; Single-pass membrane protein
• Tissue Location: Highly expressed in heart.
• Preparation and Storage: Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.

Related Product Information for SELK blocking peptide

Required for Ca(2+) flux in immune cells and plays a role in T-cell proliferation and in T-cell and neutrophil migration. Involved in endoplasmic reticulum-associated degradation (ERAD) of soluble glycosylated proteins. Required for palmitoylation and cell surface expression of CD36 and involved in macrophage uptake of low-density lipoprotein and in foam cell formation. Plays a role in protection of cells from ER stress- induced apoptosis. Protects cells from oxidative stress when overexpressed in cardiomyocytes.

NCBI and Uniprot Product Information

• NCBI GI #: 190352222
• NCBI GeneID: 58515
• UniProt Accession #: Q9Y6D0; Q8IZQ3; Q9P085
• Molecular Weight: 10,645 Da
• NCBI Official Full Name: Selenoprotein K
• NCBI Official Symbol: SELK
• NCBI Official Synonym Symbols: SelK; HSPC030; HSPC297
• NCBI Protein Information: selenoprotein K
• UniProt Protein Name: Selenoprotein K
• Protein Family: Selenoprotein
• UniProt Gene Name: SELK
• UniProt Synonym Gene Names: SelK
• UniProt Entry Name: SELK_HUMAN

NCBI Description

This gene encodes a selenoprotein, which contains a selenocysteine (Sec) residue at its active site. The selenocysteine is encoded by the UGA codon that normally signals translation termination. The 3' UTR of selenoprotein genes have a common stem-loop structure, the sec insertion sequence (SECIS), that is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. This selenoprotein is localized to the endoplasmic reticulum and is highly expressed in the heart, where it may function as an antioxidant. [provided by RefSeq, Jul 2008]

Uniprot Description

SELK: a selenoprotein, which contains a selenocysteine (Sec) residue at its active site. The selenocysteine is encoded by the UGA codon that normally signals translation termination. The 3' UTR of selenoprotein genes have a common stem-loop structure, the sec insertion sequence (SECIS), that is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. This selenoprotein is localized to the endoplasmic reticulum and is highly expressed in the heart, where it may function as an antioxidant. [provided by RefSeq, Jul 2008]

Chromosomal Location of Human Ortholog: 3p21.31

Cellular Component: endoplasmic reticulum; endoplasmic reticulum membrane

Molecular Function: identical protein binding

Biological Process: response to oxidative stress