PIK3R4 blocking peptide

PIK3R4 Antibody (Center) Blocking peptide

• Gene Names: PIK3R4; p150; VPS15
• Synonyms: PIK3R4; PIK3R4 Antibody (Center) Blocking peptide; Phosphoinositide 3-kinase regulatory subunit 4; PI3-kinase regulatory subunit 4; PI3-kinase p150 subunit; Phosphoinositide 3-kinase adaptor protein; PIK3R4 blocking peptide

• Specificity: The synthetic peptide sequence used to generate the antibody was selected from the Center region of PIK3R4. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
• Form/Format: Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
• Sequence Length: 1358

• Cellular Location: Late endosome. Note: Localizes also to discrete punctae along the ciliary axoneme
• Tissue Location: Ubiquitously expressed.
• Preparation and Storage: Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.

Related Product Information for PIK3R4 blocking peptide

Regulatory subunit of the PI3K complex. May regulate membrane trafficking late in the endocytic pathway.

NCBI and Uniprot Product Information

• NCBI GI #: 74762700
• NCBI GeneID: 30849
• UniProt Accession #: Q99570; Q2TBF4
• Molecular Weight: 153,103 Da
• NCBI Official Full Name: Phosphoinositide 3-kinase regulatory subunit 4
• NCBI Official Synonym Full Names: phosphoinositide-3-kinase regulatory subunit 4
• NCBI Official Symbol: PIK3R4
• NCBI Official Synonym Symbols: p150; VPS15
• NCBI Protein Information: phosphoinositide 3-kinase regulatory subunit 4
• UniProt Protein Name: Phosphoinositide 3-kinase regulatory subunit 4
• Protein Family: Phosphoinositide 3-kinase regulatory
• UniProt Gene Name: PIK3R4
• UniProt Synonym Gene Names: PI3-kinase regulatory subunit 4
• UniProt Entry Name: PI3R4_HUMAN

Uniprot Description

PIK3R4: Regulatory subunit of the PI3K complex. May regulate membrane trafficking late in the endocytic pathway. Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.

Protein type: Kinase, protein; Kinase, lipid; EC 2.7.11.1; Protein kinase, Ser/Thr (non-receptor); Protein kinase, Other; Other group; VPS15 family

Chromosomal Location of Human Ortholog: 3q22.1

Cellular Component: axoneme; cytosol; late endosome; membrane; nuclear pore; phagocytic vesicle membrane

Molecular Function: 1-phosphatidylinositol-3-kinase activity; protein binding; protein serine/threonine kinase activity

Biological Process: cellular response to glucose starvation; late endosome to vacuole transport; macroautophagy; peroxisome degradation; phosphatidylinositol biosynthetic process; positive regulation of phosphoinositide 3-kinase activity; protein amino acid phosphorylation; protein targeting to vacuole; receptor catabolic process; regulation of cytokinesis; toll-like receptor 9 signaling pathway