Hrk BH3 Domain Blocking Peptide | HRK blocking peptide

Hrk BH3 Domain Antibody Blocking Peptide

• Gene Names: HRK; DP5; HARAKIRI
• Synonyms: Hrk BH3 Domain; Hrk BH3 Domain Antibody Blocking Peptide; Activator of apoptosis harakiri; BH3-interacting domain-containing protein 3; Neuronal death protein DP5; HRK; BID3; HRK blocking peptide

• Specificity: The synthetic peptide sequence used to generate the antibody was selected from the region of human Hrk BH3 Domain. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
• Form/Format: The synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml deionized water for a final concentration of 1 mg/ml.
• Sequence Length: 91

• Cellular Location: Membrane; Single-pass membrane protein. Mitochondrion
• Preparation and Storage: Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.

Related Product Information for HRK blocking peptide

Promotes apoptosis.

NCBI and Uniprot Product Information

• NCBI GI #: 4504493
• NCBI GeneID: 8739
• NCBI Accession #: NP_003797
• NCBI GenBank Nucleotide #: NM_003806.2
• UniProt Accession #: O00198
• Molecular Weight: 9,884 Da
• NCBI Official Full Name: activator of apoptosis harakiri
• NCBI Official Synonym Full Names: harakiri, BCL2 interacting protein
• NCBI Official Symbol: HRK
• NCBI Official Synonym Symbols: DP5; HARAKIRI
• NCBI Protein Information: activator of apoptosis harakiri
• UniProt Protein Name: Activator of apoptosis harakiri
• Protein Family: Activator of apoptosis harakiri
• UniProt Gene Name: HRK
• UniProt Synonym Gene Names: BID3
• UniProt Entry Name: HRK_HUMAN

NCBI Description

This gene encodes a member of the BCL-2 protein family. Members of this family are involved in activating or inhibiting apoptosis. The encoded protein localizes to intracellular membranes. This protein promotes apoptosis by interacting with the apoptotic inhibitors BCL-2 and BCL-X(L) via its BH3 domain. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Oct 2012]

Uniprot Description

HRK: Promotes apoptosis.

Protein type: Membrane protein, integral; Apoptosis

Chromosomal Location of Human Ortholog: 12q24.22

Cellular Component: mitochondrion

Molecular Function: protein binding

Biological Process: positive regulation of apoptosis; positive regulation of protein homooligomerization