DCC blocking peptide

DCC Antibody (Center) Blocking peptide

• Gene Names: DCC; CRC18; CRCR1; MRMV1; IGDCC1; NTN1R1
• Synonyms: DCC; DCC Antibody (Center) Blocking peptide; Netrin receptor DCC; Colorectal cancer suppressor; Immunoglobulin superfamily DCC subclass member 1; Tumor suppressor protein DCC; IGDCC1; DCC blocking peptide

• Form/Format: Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
• Sequence Length: 1447

• Cellular Location: Membrane; Single-pass type I membrane protein
• Tissue Location: Found in axons of the central and peripheral nervous system and in differentiated cell types of the intestine Not expressed in colorectal tumor cells that lost their capacity to differentiate into mucus producing cells
• Preparation and Storage: Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.

Related Product Information for DCC blocking peptide

Receptor for netrin required for axon guidance. Mediates axon attraction of neuronal growth cones in the developing nervous system upon ligand binding. Its association with UNC5 proteins may trigger signaling for axon repulsion. It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand. Implicated as a tumor suppressor gene.

NCBI and Uniprot Product Information

• NCBI GI #: 296434474
• NCBI GeneID: 1630
• UniProt Accession #: P43146
• Molecular Weight: 158,457 Da
• NCBI Official Full Name: Netrin receptor DCC
• NCBI Official Synonym Full Names: DCC netrin 1 receptor
• NCBI Official Symbol: DCC
• NCBI Official Synonym Symbols: CRC18; CRCR1; MRMV1; IGDCC1; NTN1R1
• NCBI Protein Information: netrin receptor DCC
• UniProt Protein Name: Netrin receptor DCC
• Protein Family: DCC family protein
• UniProt Gene Name: DCC
• UniProt Synonym Gene Names: IGDCC1
• UniProt Entry Name: DCC_HUMAN

NCBI Description

This gene encodes a netrin 1 receptor. The transmembrane protein is a member of the immunoglobulin superfamily of cell adhesion molecules, and mediates axon guidance of neuronal growth cones towards sources of netrin 1 ligand. The cytoplasmic tail interacts with the tyrosine kinases Src and focal adhesion kinase (FAK, also known as PTK2) to mediate axon attraction. The protein partially localizes to lipid rafts, and induces apoptosis in the absence of ligand. The protein functions as a tumor suppressor, and is frequently mutated or downregulated in colorectal cancer and esophageal carcinoma. [provided by RefSeq, Oct 2009]

Uniprot Description

DCC: Receptor for netrin required for axon guidance. Mediates axon attraction of neuronal growth cones in the developing nervous system upon ligand binding. Its association with UNC5 proteins may trigger signaling for axon repulsion. It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand. Implicated as a tumor suppressor gene. Defects in DCC are the cause of mirror movements type 1 (MRMV1). A disorder characterized by contralateral involuntary movements that mirror voluntary ones. While mirror movements are occasionally found in young children, persistence beyond the age of 10 is abnormal. Mirror movements occur more commonly in the upper extremities. Belongs to the immunoglobulin superfamily. DCC family.

Protein type: Receptor, misc.; Membrane protein, integral; Immunoglobulin superfamily; Tumor suppressor

Chromosomal Location of Human Ortholog: 18q21.3

Cellular Component: cytosol; plasma membrane

Molecular Function: protein binding; transmembrane receptor activity

Biological Process: apoptosis; axon guidance; axonogenesis; negative regulation of collateral sprouting

Disease: Colorectal Cancer; Esophageal Cancer; Mirror Movements 1