CRFR1 (Q103) Blocking Peptide | CRHR1 blocking peptide

CRFR1 Antibody (Q103) Blocking peptide

• Synonyms: CRFR1 (Q103); CRFR1 Antibody (Q103) Blocking peptide; Corticotropin-releasing factor receptor 1; CRF-R-1; CRF-R1; CRFR-1; Corticotropin-releasing hormone receptor 1; CRH-R-1; CRH-R1; CRHR1; CRFR; CRFR1; CRHR; CRHR1 blocking peptide

• Form/Format: Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
• Sequence Length: 444

• Cellular Location: Cell membrane; Multi-pass membrane protein. Endosome. Note: Agonist-binding promotes endocytosis
• Tissue Location: Predominantly expressed in the cerebellum, pituitary, cerebral cortex and olfactory lobe
• Preparation and Storage: Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.

Related Product Information for CRHR1 blocking peptide

G-protein coupled receptor for CRH (corticotropin- releasing factor) and UCN (urocortin). Has high affinity for CRH and UCN. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and down-stream effectors, such as adenylate cyclase. Promotes the activation of adenylate cyclase, leading to increased intracellular cAMP levels. Inhibits the activity of the calcium channel CACNA1H. Required for normal embryonic development of the adrenal gland and for normal hormonal responses to stress. Plays a role in the response to anxiogenic stimuli.

NCBI and Uniprot Product Information

• NCBI GI #: 461836
• NCBI GeneID: 104909134
• UniProt Accession #: P34998; Q13008; Q4QRJ1; Q9UK64; B4DIE9
• Molecular Weight: 28,122 Da
• NCBI Official Full Name: Corticotropin-releasing factor receptor 1
• NCBI Official Symbol: MGC57346-CRHR1
• NCBI Protein Information: MGC57346-CRHR1 protein
• UniProt Protein Name: Corticotropin-releasing factor receptor 1
• Protein Family: Corticotropin-releasing factor receptor
• UniProt Gene Name: CRHR1
• UniProt Synonym Gene Names: CRFR; CRFR1; CRHR; CRF-R-1; CRF-R1; CRFR-1; CRH-R-1; CRH-R1
• UniProt Entry Name: CRFR1_HUMAN

NCBI Description

This locus represents naturally occurring readthrough transcription between neighboring GeneID:401884 (ADP-ribosylation factor 3 pseudogene) and GeneID:1394 (CRHR1, corticotropin releasing hormone receptor 1) on chromosome 17. The readthrough transcript encodes a protein that shares sequence identity with the product of the CRHR1 gene. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2014]

Uniprot Description

CRF-R1: a G-protein coupled receptor that specifically binds corticotropin-releasing hormone, a potent mediator of endocrine, autonomic, behavioral, and immune responses to stress. Four splice-variant isoforms have been described.

Protein type: Membrane protein, integral; Receptor, GPCR; Membrane protein, multi-pass; GPCR, family 2

Chromosomal Location of Human Ortholog: 17q21.31

Cellular Component: integral to membrane; integral to plasma membrane; intrinsic to plasma membrane; plasma membrane

Molecular Function: corticotrophin-releasing factor receptor activity; protein binding

Biological Process: adenylate cyclase activation; adrenocorticotropin hormone secretion; immune response; parturition