GNL3L blocking peptide

GNL3L Antibody (N-term) Blocking peptide

• Gene Names: GNL3L; GNL3B
• Synonyms: GNL3L; GNL3L Antibody (N-term) Blocking peptide; Guanine nucleotide-binding protein-like 3-like protein; GNL3L blocking peptide

• Form/Format: Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
• Sequence Length: 582

• Cellular Location: Nucleus, nucleolus
• Preparation and Storage: Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.

Related Product Information for GNL3L blocking peptide

Stabilizes TERF1 telomeric association by preventing TERF1 recruitment by PML. Stabilizes TERF1 protein by preventing its ubiquitination and hence proteasomal degradation. Does so by interfering with TERF1-binding to FBXO4 E3 ubiquitin-protein ligase. Required for cell proliferation. By stabilizing TRF1 protein during mitosis, promotes metaphase-to-anaphase transition. Stabilizes MDM2 protein by preventing its ubiquitination, and hence proteasomal degradation. By acting on MDM2, may affect TP53 activity. Required for normal processing of ribosomal pre-rRNA. Binds GTP.

NCBI and Uniprot Product Information

• NCBI GI #: 74752999
• NCBI GeneID: 54552
• UniProt Accession #: Q9NVN8
• Molecular Weight: 65,573 Da
• NCBI Official Full Name: Guanine nucleotide-binding protein-like 3-like protein
• NCBI Official Synonym Full Names: G protein nucleolar 3 like
• NCBI Official Symbol: GNL3L
• NCBI Official Synonym Symbols: GNL3B
• NCBI Protein Information: guanine nucleotide-binding protein-like 3-like protein
• UniProt Protein Name: Guanine nucleotide-binding protein-like 3-like protein
• Protein Family: Guanine nucleotide-binding protein-like 3-like protein
• UniProt Gene Name: GNL3L
• UniProt Entry Name: GNL3L_HUMAN

NCBI Description

The protein encoded by this gene appears to be a nucleolar GTPase that is essential for ribosomal pre-rRNA processing and cell proliferation. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, May 2010]

Uniprot Description

GNL3L: Stabilizes TERF1 telomeric association by preventing TERF1 recruitment by PML. Stabilizes TERF1 protein by preventing its ubiquitination and hence proteasomal degradation. Does so by interfering with TERF1-binding to FBXO4 E3 ubiquitin-protein ligase. Required for cell proliferation. By stabilizing TRF1 protein during mitosis, promotes metaphase-to-anaphase transition. Stabilizes MDM2 protein by preventing its ubiquitination, and hence proteasomal degradation. By acting on MDM2, may affect TP53 activity. Required for normal processing of ribosomal pre-rRNA. Binds GTP. Belongs to the MMR1/HSR1 GTP-binding protein family.

Protein type: Nucleolus

Chromosomal Location of Human Ortholog: Xp11.22

Cellular Component: cytoplasm; membrane; mitochondrion; nucleolus; nucleus; telomerase holoenzyme complex

Molecular Function: GTPase activity; protein binding

Biological Process: negative regulation of protein binding; negative regulation of protein sumoylation; negative regulation of protein ubiquitination; negative regulation of telomere maintenance via telomerase; regulation of protein stability; ribosome biogenesis and assembly