TDRD7 blocking peptide

TDRD7 Antibody (C-term) Blocking peptide

• Gene Names: TDRD7; TRAP; CATC4; PCTAIRE2BP
• Synonyms: TDRD7; TDRD7 Antibody (C-term) Blocking peptide; Tudor domain-containing protein 7; PCTAIRE2-binding protein; Tudor repeat associator with PCTAIRE-2; Trap; PCTAIRE2BP; TDRD7 blocking peptide

• Form/Format: Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
• Sequence Length: 1098

• Cellular Location: Cytoplasm. Note: Localizes to cytoplasmic RNA granules. Present in chromatoid body (CB) of spermatids (mammalian counterpart of germplasm, pole plasm or polar granules in Drosophila germ cells), also named processing bodies (P-bodies) in somatic cells. Detected in the multilobular cytoplasmic CBs (also called intermitochondrial cementin) in pachytene spermatocytes and as a single perinuclear CB in haploid round spermatids (By similarity).
• Preparation and Storage: Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.

Related Product Information for TDRD7 blocking peptide

Component of specific cytoplasmic RNA granules involved in post-transcriptional regulation of specific genes: probably acts by binding to specific mRNAs and regulating their translation. Required for lens transparency during lens development, by regulating translation of genes such as CRYBB3 and HSPB1 in the developing lens. Also required during spermatogenesis.

NCBI and Uniprot Product Information

• NCBI GI #: 152031705
• NCBI GeneID: 23424
• UniProt Accession #: Q8NHU6; Q5VV27; Q96JT1; Q9UFF0; Q9Y2M3; A6NCI6; B2RBX3; B4DG99; B4DXF7; E7EQD4
• Molecular Weight: 47,539 Da
• NCBI Official Full Name: Tudor domain-containing protein 7
• NCBI Official Synonym Full Names: tudor domain containing 7
• NCBI Official Symbol: TDRD7
• NCBI Official Synonym Symbols: TRAP; CATC4; PCTAIRE2BP
• NCBI Protein Information: tudor domain-containing protein 7
• UniProt Protein Name: Tudor domain-containing protein 7
• Protein Family: Tudor domain-containing protein
• UniProt Gene Name: TDRD7
• UniProt Synonym Gene Names: PCTAIRE2BP; Trap
• UniProt Entry Name: TDRD7_HUMAN

NCBI Description

The protein encoded by this gene belongs to the Tudor family of proteins. This protein contains conserved Tudor domains and LOTUS domains. It is a component of RNA granules, which function in RNA processing. Mutations in this gene have been associated with cataract formation in mouse and human. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2014]

Uniprot Description

TDRD7: Component of specific cytoplasmic RNA granules involved in post-transcriptional regulation of specific genes: probably acts by binding to specific mRNAs and regulating their translation. Required for lens transparency during lens development, by regulating translation of genes such as CRYBB3 and HSPB1 in the developing lens. Also required during spermatogenesis. Defects in TDRD7 are the cause of cataract congenital autosomal recessive type 4 (CATC4). An opacification of the crystalline lens of the eye becoming evident at birth. It frequently results in visual impairment or blindness. Opacities vary in morphology, are often confined to a portion of the lens, and may be static or progressive. In general, the more posteriorly located and dense an opacity, the greater the impact on visual function. Belongs to the TDRD7 family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Adaptor/scaffold

Chromosomal Location of Human Ortholog: 9q22.33

Cellular Component: cytoplasm

Molecular Function: mRNA binding; protein binding

Biological Process: lens morphogenesis in camera-type eye; spermatogenesis

Disease: Cataract 36