PMAT (Slc29a4) Blocking Peptide | Slc29a4 blocking peptide

PMAT(Slc29a4) Antibody (C-term) Blocking Peptide

• Gene Names: Slc29a4; ENT4; mPMAT
• Synonyms: PMAT (Slc29a4); PMAT(Slc29a4) Antibody (C-term) Blocking Peptide; Equilibrative nucleoside transporter 4; Solute carrier family 29 member 4; Slc29a4; Ent4; Slc29a4 blocking peptide

• Specificity: The synthetic peptide sequence used to generate the antibody was selected from the Slc29a4 region of human PMAT(Slc29a4). A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
• Form/Format: Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
• Sequence Length: 528

• Cellular Location: Cell membrane; Multi-pass membrane protein. Apical cell membrane; Multi-pass membrane protein Note: Located to the plasma membranes of ventricular myocytes and vascular endothelial cells. Targeted to the apical membranes of differentiated kidney epithelial cells (By similarity)
• Tissue Location: Expressed in heart.
• Preparation and Storage: Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.

Related Product Information for Slc29a4 blocking peptide

Functions as a polyspecific organic cation transporter, efficiently transporting many organic cations such as monoamine neurotransmitters 1-methyl-4-phenylpyridinium and biogenic amines including serotonin, dopamine, norepinephrine and epinephrine. May play a role in regulating central nervous system homeostasis of monoamine neurotransmitters. May be involved in luminal transport of organic cations in the kidney and seems to use luminal proton gradient to drive organic cation reabsorptprev reabsorption. Does not seem to transport nucleoside and nucleoside analogs such as uridine, cytidine, thymidine, adenosine, inosine, guanosine, and azidothymidine. In (PubMed:16873718) adenosine is efficiently transported but in a fashion highly sensitive to extracellular pH, with maximal activity in the pH range 5.5 to 6.5. Glu-206 is essential for the cation selectivity and may function as the charge sensor for cationic substrates. Transport is chloride and sodium-independent but appears to be sensitive to changes in membrane potential. Weakly inhibited by the classical inhibitors of equilibrative nucleoside transport, dipyridamole, dilazep, and nitrobenzylthioinosine. May play a role in the regulation of extracellular adenosine concentrations in cardiac tissues, in particular during ischemia (By similarity).

NCBI and Uniprot Product Information

• NCBI GI #: 81878850
• NCBI GeneID: 243328
• UniProt Accession #: Q8R139
• Molecular Weight: 58,099 Da
• NCBI Official Full Name: Equilibrative nucleoside transporter 4
• NCBI Official Synonym Full Names: solute carrier family 29 (nucleoside transporters), member 4
• NCBI Official Symbol: Slc29a4
• NCBI Official Synonym Symbols: ENT4; mPMAT
• NCBI Protein Information: equilibrative nucleoside transporter 4
• UniProt Protein Name: Equilibrative nucleoside transporter 4
• Protein Family: Equilibrative nucleoside transporter
• UniProt Gene Name: Slc29a4
• UniProt Synonym Gene Names: Ent4
• UniProt Entry Name: S29A4_MOUSE

Uniprot Description

SLC29A4: Functions as a polyspecific organic cation transporter, efficiently transporting many organic cations such as monoamine neurotransmitters 1-methyl-4-phenylpyridinium and biogenic amines including serotonin, dopamine, norepinephrine and epinephrine. May play a role in regulating central nervous system homeostasis of monoamine neurotransmitters. May be involved in luminal transport of organic cations in the kidney and seems to use luminal proton gradient to drive organic cation reabsorption. Does not seem to transport nucleoside and nucleoside analogs such as uridine, cytidine, thymidine, adenosine, inosine, guanosine, and azidothymidine. In (PubMed:16873718) adenosine is efficiently transported but in a fashion highly sensitive to extracellular pH, with maximal activity in the pH range 5.5 to 6.5. Glu-206 is essential for the cation selectivity and may function as the charge sensor for cationic substrates. Transport is chloride and sodium-independent but appears to be sensitive to changes in membrane potential. Weakly inhibited by the classical inhibitors of equilibrative nucleoside transport, dipyridamole, dilazep, and nitrobenzylthioinosine. May play a role in the regulation of extracellular adenosine concentrations in cardiac tissues, in particular during ischemia. Belongs to the SLC29A/ENT transporter (TC 2.A.57) family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Transporter; Membrane protein, integral; Transporter, SLC family; Membrane protein, multi-pass

Cellular Component: plasma membrane

Molecular Function: monoamine transmembrane transporter activity

Biological Process: monoamine transport