Rabbit anti-Human MT-CO2 Polyclonal Antibody | anti-MT-CO2 antibody

MT-CO2 Antibody (C-term)

Cat. Num. AAA9216005

• Gene Names: MT-CO2; COII; MTCO2; COX2
• Reactivity: Human
• Applications: Western Blot
• Synonyms: MT-CO2; Polyclonal Antibody; MT-CO2 Antibody (C-term); Purified Rabbit Polyclonal Antibody (Pab); Cytochrome c oxidase subunit 2; Cytochrome c oxidase polypeptide II; COII; COXII; MTCO2; anti-MT-CO2 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: Ig
• Specificity: This MT-CO2 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 169-201 amino acids from the C-terminal region of human MT-CO2.
• Form/Format: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
• Sequence Length: 227

• Applicable Applications for anti-MT-CO2 antibody: Western Blot (WB)
• Application Notes: WB ~~ 1:2000
• Antigen Source: Human
• Preparation and Storage: Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C in small aliquots to prevent freeze-thaw cycles.

Western Blot (WB)

(All lanes : Anti-MTCO2 Antibody (Cterm) at 1:2000 dilutionLane 1: human heart lysateLane 2: human liver lysateLane 3: Hela whole cell lysateLane 4: K562 whole cell lysateLane 5: MCF-7 whole cell lysateLane 6: THP-1 whole cell lysateLysates/proteins at 20 ug per lane.SecondaryGoat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/10000 dilution.Predicted band size : 26 kDaBlocking/Dilution buffer: 5% NFDM/TBST.)

Related Product Information for anti-MT-CO2 antibody

Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. Subunit 2 transfers the electrons from cytochrome c via its binuclear copper A center to the bimetallic center of the catalytic subunit 1.

Product Categories/Family for anti-MT-CO2 antibody

Cancer; Metabolism; Signal Transduction

References

Anderson S.,et al.Nature 290:457-465(1981). Power M.D.,et al.Nucleic Acids Res. 17:6734-6734(1989). Barrell B.G.,et al.Nature 282:189-194(1979). Horai S.,et al.Proc. Natl. Acad. Sci. U.S.A. 92:532-536(1995). Ruvolo M.,et al.Mol. Biol. Evol. 10:1115-1135(1993).

NCBI and Uniprot Product Information

• NCBI GI #: 251831110
• NCBI GeneID: 4513
• NCBI Accession #: YP_003024029.1
• NCBI GenBank Nucleotide #: NC_012920.1
• UniProt Accession #: P00403; Q37526
• Molecular Weight: 25565
• NCBI Official Full Name: cytochrome c oxidase subunit II (mitochondrion)
• NCBI Official Synonym Full Names: mitochondrially encoded cytochrome c oxidase II
• NCBI Official Symbol: MT-CO2
• NCBI Official Synonym Symbols: COII; MTCO2; COX2
• NCBI Protein Information: cytochrome c oxidase subunit II
• UniProt Protein Name: Cytochrome c oxidase subunit 2
• UniProt Gene Name: MT-CO2
• UniProt Synonym Gene Names: COII; COXII; MTCO2
• UniProt Entry Name: COX2_HUMAN

NCBI Description

COX2: Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. Subunit 2 transfers the electrons from cytochrome c via its binuclear copper A center to the bimetallic center of the catalytic subunit 1. Defects in MT-CO2 are a cause of mitochondrial complex IV deficiency (MT-C4D); also known as cytochrome c oxidase deficiency. A disorder of the mitochondrial respiratory chain with heterogeneous clinical manifestations, ranging from isolated myopathy to severe multisystem disease affecting several tissues and organs. Features include hypertrophic cardiomyopathy, hepatomegaly and liver dysfunction, hypotonia, muscle weakness, excercise intolerance, developmental delay, delayed motor development and mental retardation. A subset of patients manifest Leigh syndrome. Belongs to the cytochrome c oxidase subunit 2 family.

Protein type: Energy Metabolism - oxidative phosphorylation; Oxidoreductase; Membrane protein, multi-pass; Mitochondrial; Membrane protein, integral; EC 1.9.3.1

Chromosomal Location of Human Ortholog: -

Disease: Mitochondrial Myopathy, Encephalopathy, Lactic Acidosis, And Stroke-like Episodes

Uniprot Description

COX2: Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. Subunit 2 transfers the electrons from cytochrome c via its binuclear copper A center to the bimetallic center of the catalytic subunit 1. Defects in MT-CO2 are a cause of mitochondrial complex IV deficiency (MT-C4D); also known as cytochrome c oxidase deficiency. A disorder of the mitochondrial respiratory chain with heterogeneous clinical manifestations, ranging from isolated myopathy to severe multisystem disease affecting several tissues and organs. Features include hypertrophic cardiomyopathy, hepatomegaly and liver dysfunction, hypotonia, muscle weakness, excercise intolerance, developmental delay, delayed motor development and mental retardation. A subset of patients manifest Leigh syndrome. Belongs to the cytochrome c oxidase subunit 2 family.

Protein type: Membrane protein, multi-pass; Energy Metabolism - oxidative phosphorylation; EC 1.9.3.1; Membrane protein, integral; Mitochondrial; Oxidoreductase

Chromosomal Location of Human Ortholog: -

Disease: Mitochondrial Myopathy, Encephalopathy, Lactic Acidosis, And Stroke-like Episodes