Western Blot (WB)
(ROBLD3 Antibody (Center) western blot analysis in HL-60 cell line lysates (35ug/lane).This demonstrates the ROBLD3 antibody detected the ROBLD3 protein (arrow).)
Rabbit ROBLD3 Polyclonal Antibody | anti-LAMTOR2 antibody
ROBLD3 Antibody (Center)
Western Blot (WB)
(ROBLD3 Antibody (Center) western blot analysis in HL-60 cell line lysates (35ug/lane).This demonstrates the ROBLD3 antibody detected the ROBLD3 protein (arrow).)
Western Blot (WB)
(ROBLD3 Antibody (Center) western blot analysis in HL-60 cell line lysates (35ug/lane).This demonstrates the ROBLD3 antibody detected the ROBLD3 protein (arrow).)
Immunohistochemistry (IHC)
(ROBLD3 Antibody (Center) immunohistochemistry analysis in formalin fixed and paraffin embedded human stomach tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of ROBLD3 Antibody (Center) for immunohistochemistry. Clinical relevance has not been evaluated.)
Immunohistochemistry (IHC)
(ROBLD3 Antibody (Center) immunohistochemistry analysis in formalin fixed and paraffin embedded human stomach tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of ROBLD3 Antibody (Center) for immunohistochemistry. Clinical relevance has not been evaluated.)
protein associated with the cytoplasmic face of late endosomes and
lysosomes. The mouse protein interacts with MAPK scaffold protein
1, a component of the mitogen-activated protein kinase pathway. In
humans, a mutation in this gene has been associated with a primary
immunodeficiency syndrome, and suggests a role for this protein in
endosomal biogenesis. Multiple transcript variants encoding
different isoforms have been found for this gene. [provided by
RefSeq].
Wunderlich, W., et al. J. Cell Biol. 152(4):765-776(2001)
NCBI and Uniprot Product Information
NCBI Description
The product of this gene is highly conserved with a mouse protein associated with the cytoplasmic face of late endosomes and lysosomes. The mouse protein interacts with MAPK scaffold protein 1, a component of the mitogen-activated protein kinase pathway. In humans, a mutation in this gene has been associated with a primary immunodeficiency syndrome, and suggests a role for this protein in endosomal biogenesis. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2009]
Uniprot Description
LAMTOR2: Adapter protein that enhances the efficiency of the MAP kinase cascade. Facilitates the activation of MAPKAPK2 . Heterodimer with MAP2K1IP1. Interacts with ERK and MEK1. Defects in ROBLD3 are the cause of immunodeficiency due to defect in MAPBP-interacting protein. This form of primary immunodeficiency syndrome includes congenital neutropenia, partial albinism, short stature and B-cell and cytotoxic T-cell deficiency. Two alternatively spliced isoforms of the human protein have been described.
Protein type: Adaptor/scaffold
Chromosomal Location of Human Ortholog: 1q22
Cellular Component: lysosomal membrane; late endosome
Molecular Function: protein binding; guanyl-nucleotide exchange factor activity; protein complex scaffold
Biological Process: activation of MAPKK activity; cell growth; positive regulation of TOR signaling pathway; positive regulation of GTPase activity
Disease: Immunodeficiency Due To Defect In Mapbp-interacting Protein
Research Articles on LAMTOR2
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Product Notes
The LAMTOR2 lamtor2 (Catalog #AAA9212404) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 41-70. The ROBLD3 Antibody (Center) reacts with Human (Predicted Reactivity: Bovine) and may cross-react with other species as described in the data sheet. AAA Biotech's ROBLD3 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), ELISA (EIA), Immunohistochemistry (IHC). WB~~1:1000. Researchers should empirically determine the suitability of the LAMTOR2 lamtor2 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "ROBLD3, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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