Western Blot (WB)
(The anti-CBX8 C-term Pab is used in Western blot to detect CBX8 in mouse kidney tissue lysate.)
Rabbit anti-Human, mouse CBX8 Polyclonal Antibody | anti-CBX8 antibody
CBX8 Antibody (C-term)
Western Blot (WB)
(The anti-CBX8 C-term Pab is used in Western blot to detect CBX8 in mouse kidney tissue lysate.)
Western Blot (WB)
(The anti-CBX8 C-term Pab is used in Western blot to detect CBX8 in mouse kidney tissue lysate.)
Immunohistochemistry (IHC)
(Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. BC = breast carcinoma; HC = hepatocarcinoma.)
Immunohistochemistry (IHC)
(Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. BC = breast carcinoma; HC = hepatocarcinoma.)
Western Blot (WB)
(CBX8 Antibody (Y321) western blot analysis in Hela cell line lysates (35ug/lane).This demonstrates the CBX8 antibody detected the CBX8 protein (arrow).)
Western Blot (WB)
(CBX8 Antibody (Y321) western blot analysis in Hela cell line lysates (35ug/lane).This demonstrates the CBX8 antibody detected the CBX8 protein (arrow).)
Strausberg, R.L., et al., Proc. Natl. Acad. Sci. U.S.A. 99(26):16899-16903 (2002).
Bardos, J.I., et al., J. Biol. Chem. 275(37):28785-28792 (2000).
NCBI and Uniprot Product Information
Uniprot Description
CBX8: Component of a Polycomb group (PcG) multiprotein PRC1- like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility.
Protein type: Transcription, coactivator/corepressor
Chromosomal Location of Human Ortholog: 17q25.3
Cellular Component: nucleoplasm; heterochromatin; nuclear chromatin; PcG protein complex; nucleus
Molecular Function: protein binding; single-stranded RNA binding; ubiquitin-protein ligase activity; methylated histone residue binding
Biological Process: transcription, DNA-dependent; histone ubiquitination; negative regulation of transcription from RNA polymerase II promoter
Research Articles on CBX8
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Product Notes
The CBX8 cbx8 (Catalog #AAA9210651) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 306-337. The CBX8 Antibody (C-term) reacts with Human, mouse and may cross-react with other species as described in the data sheet. AAA Biotech's CBX8 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), ELISA (EIA), Immunohistochemistry (IHC). WB~~1:1000. Researchers should empirically determine the suitability of the CBX8 cbx8 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "CBX8, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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