Western Blot (WB)
(Western blot analysis of DLX5 (arrow) using rabbit polyclonal DLX5 Antibody (Center). 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected (Lane 2) with the DLX5 gene.)
Rabbit anti-Human DLX5 Polyclonal Antibody | anti-DLX5 antibody
DLX5 Antibody (Center)
Western Blot (WB)
(Western blot analysis of DLX5 (arrow) using rabbit polyclonal DLX5 Antibody (Center). 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected (Lane 2) with the DLX5 gene.)
Western Blot (WB)
(Western blot analysis of DLX5 (arrow) using rabbit polyclonal DLX5 Antibody (Center). 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected (Lane 2) with the DLX5 gene.)
Western Blot (WB)
(DLX5 Antibody (Center) western blot analysis in HL-60 cell line lysates (35ug/lane).This demonstrates the DLX5 antibody detected the DLX5 protein (arrow).)
Western Blot (WB)
(DLX5 Antibody (Center) western blot analysis in HL-60 cell line lysates (35ug/lane).This demonstrates the DLX5 antibody detected the DLX5 protein (arrow).)
Western Blot (WB)
(DLX5 Antibody (Center) western blot analysis in mouse heart tissue lysates (35ug/lane).This demonstrates the DLX5 antibody detected the DLX5 protein (arrow).)
Western Blot (WB)
(DLX5 Antibody (Center) western blot analysis in mouse heart tissue lysates (35ug/lane).This demonstrates the DLX5 antibody detected the DLX5 protein (arrow).)
Immunohistochemistry (IHC)
(DLX5 Antibody (Center) (MBS9208393)immunohistochemistry analysis in formalin fixed and paraffin embedded human stomach tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of DLX5 Antibody (Center) for immunohistochemistry. Clinical relevance has not been evaluated.)
Immunohistochemistry (IHC)
(DLX5 Antibody (Center) (MBS9208393)immunohistochemistry analysis in formalin fixed and paraffin embedded human stomach tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of DLX5 Antibody (Center) for immunohistochemistry. Clinical relevance has not been evaluated.)
factor gene family similiar to the Drosophila distal-less gene. The
encoded protein may play a role in bone development and fracture
healing. Mutation in this gene, which is located in a tail-to-tail
configuration with another member of the family on the long arm of
chromosome 7, may be associated with split-hand/split-foot
malformation.
Jugessur, A., et al. PLoS ONE 5 (7), E11493 (2010) :
Yerges, L.M., et al. J. Bone Miner. Res. 24(12):2039-2049(2009)
Xu, J., et al. J. Biol. Chem. 284(31):20593-20601(2009)
Kato, T., et al. Clin. Cancer Res. 14(8):2363-2370(2008)
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a member of a homeobox transcription factor gene family similiar to the Drosophila distal-less gene. The encoded protein may play a role in bone development and fracture healing. Mutation in this gene, which is located in a tail-to-tail configuration with another member of the family on the long arm of chromosome 7, may be associated with split-hand/split-foot malformation. [provided by RefSeq, Jul 2008]
Uniprot Description
DLX5: Transcriptional factor involved in bone development. Acts as an immediate early BMP-responsive transcriptional activator essential for osteoblast differentiation. Stimulates ALPL promoter activity in a RUNX2-independent manner during osteoblast differentiation. Stimulates SP7 promoter activity during osteoblast differentiation. Promotes cell proliferation by up-regulating MYC promoter activity. Involved as a positive regulator of both chondrogenesis and chondrocyte hypertrophy in the endochondral skeleton. Binds to the homeodomain-response element of the ALPL and SP7 promoter. Binds to the MYC promoter. Requires the 5'-TAATTA-3' consensus sequence for DNA-binding. Defects in DLX5 are the cause of split-hand/foot malformation type 1, with sensorineural hearing loss (SHFM1D). A disease characterized by the association of split- hand/foot malformation with deafness. Split-hand/foot malformation is a limb malformation involving the central rays of the autopod and presenting with syndactyly, median clefts of the hands and feet, and aplasia and/or hypoplasia of the phalanges, metacarpals, and metatarsals. Some patients have been found to have mental retardation, ectodermal and craniofacial findings, and orofacial clefting. Belongs to the distal-less homeobox family.
Protein type: DNA-binding; Transcription factor
Chromosomal Location of Human Ortholog: 7q22
Cellular Component: cytoplasm; nuclear chromatin
Biological Process: axon guidance; nervous system development; inner ear morphogenesis; transcription, DNA-dependent; positive regulation of transcription, DNA-dependent; olfactory pit development; palate development; osteoblast differentiation; BMP signaling pathway; positive regulation of osteoblast differentiation; cell proliferation; epithelial cell differentiation; anatomical structure formation; skeletal development; positive regulation of epithelial cell proliferation; endochondral ossification; embryonic limb morphogenesis
Disease: Split-hand/foot Malformation 1 With Sensorineural Hearing Loss, Autosomal Recessive
Research Articles on DLX5
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Product Notes
The DLX5 dlx5 (Catalog #AAA9208393) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 100-128. The DLX5 Antibody (Center) reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's DLX5 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), ELISA (EIA), Immunohistochemistry (IHC). WB~~1:1000. Researchers should empirically determine the suitability of the DLX5 dlx5 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "DLX5, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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