Western Blot (WB)
(GNAQ Antibody (N-term) western blot analysis in human placenta tissue lysates (35ug/lane).This demonstrates the GNAQ antibody detected the GNAQ protein (arrow).)
Rabbit GNAQ Polyclonal Antibody | anti-GNAQ antibody
GNAQ Antibody (N-term)
Western Blot (WB)
(GNAQ Antibody (N-term) western blot analysis in human placenta tissue lysates (35ug/lane).This demonstrates the GNAQ antibody detected the GNAQ protein (arrow).)
Western Blot (WB)
(GNAQ Antibody (N-term) western blot analysis in human placenta tissue lysates (35ug/lane).This demonstrates the GNAQ antibody detected the GNAQ protein (arrow).)
Western Blot (WB)
(Western blot analysis of GNAQ (arrow) using rabbit polyclonal GNAQ Antibody (N-term). 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected (Lane 2) with the GNAQ gene.)
Western Blot (WB)
(Western blot analysis of GNAQ (arrow) using rabbit polyclonal GNAQ Antibody (N-term). 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected (Lane 2) with the GNAQ gene.)
The encoded protein, an alpha subunit in the Gq class, couples a
seven-transmembrane domain receptor to activation of phospolipase
C-beta. Mutations at this locus have been associated with problems
in platelet activation and aggregation. A related pseudogene exists
on chromosome 2.
Crouthamel, M., et al. Mol. Pharmacol. 78(4):767-777(2010)
Chillar, A., et al. Biochemistry 49(30):6365-6374(2010)
Klenke, S., et al. Pharmacogenet. Genomics 20(8):476-484(2010)
Salmanian, S., et al. Biochem. Biophys. Res. Commun. 395(4):577-582(2010)
NCBI and Uniprot Product Information
NCBI Description
This locus encodes a guanine nucleotide-binding protein. The encoded protein, an alpha subunit in the Gq class, couples a seven-transmembrane domain receptor to activation of phospolipase C-beta. Mutations at this locus have been associated with problems in platelet activation and aggregation. A related pseudogene exists on chromosome 2.[provided by RefSeq, Nov 2010]
Uniprot Description
G-alpha(q): a guanine nucleotide-binding protein of the G12 class of G-alpha proteins. Agonist binding to Gq-coupled receptors may block Akt activation via the release of active G-alpha(q) subunits that inhibit phosphatidylinositol 3-kinase. Heterotrimeric G proteins are composed of 3 units; alpha, beta and gamma. The alpha chain contains the guanine nucleotide binding site.
Protein type: G protein, heterotrimeric; G protein, heterotrimeric alpha G(q); G protein
Chromosomal Location of Human Ortholog: 9q21
Cellular Component: nuclear membrane; lysosomal membrane; cytoplasm; plasma membrane; heterotrimeric G-protein complex
Molecular Function: GTPase activity; protein binding; signal transducer activity; GTP binding; type 2A serotonin receptor binding; metal ion binding; G-protein beta/gamma-subunit binding; GTPase activator activity
Biological Process: regulation of action potential; platelet activation; protein stabilization; glutamate signaling pathway; maternal behavior; metabolic process; heart development; pigmentation during development; G-protein signaling, adenylate cyclase activating pathway; regulation of melanocyte differentiation; post-embryonic development; phospholipase C activation; forebrain neuron development; negative regulation of protein kinase activity; embryonic digit morphogenesis; dopamine receptor, phospholipase C activating pathway; blood coagulation; skeletal development; positive regulation of GTPase activity; neuron remodeling
Disease: Sturge-weber Syndrome; Capillary Malformations, Congenital
Research Articles on GNAQ
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Product Notes
The GNAQ gnaq (Catalog #AAA9205969) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 52-78. The GNAQ Antibody (N-term) reacts with Human (Predicted Reactivity: Mouse, Pig, Rat, Xenopus) and may cross-react with other species as described in the data sheet. AAA Biotech's GNAQ can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), ELISA (EIA). WB~~1:1000. Researchers should empirically determine the suitability of the GNAQ gnaq for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "GNAQ, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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