Rabbit anti-Human, mouse EDG6 Polyclonal Antibody | anti-S1PR4 antibody

EDG6 Antibody (N-term)

Cat. Num. AAA9204739

• Gene Names: S1PR4; EDG6; LPC1; S1P4; SLP4
• Reactivity: Human, mouse
• Applications: Western Blot, ELISA
• Purity: Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)
• Synonyms: EDG6; Polyclonal Antibody; EDG6 Antibody (N-term); Sphingosine 1-phosphate receptor 4; S1P receptor 4; S1P4; Endothelial differentiation G-protein coupled receptor 6; Sphingosine 1-phosphate receptor Edg-6; S1P receptor Edg-6; S1PR4; anti-S1PR4 antibody

• Host: Rabbit
• Reactivity: Human, mouse
• Clonality: Polyclonal
• Isotype: Rabbit Ig
• Specificity: This EDG6 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 8-37 amino acids from the N-terminal region of human EDG6.
• Purity/Purification: Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)
• Form/Format: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
• Concentration: Vial Concentration: 0.29 (varies by lot)
• Sequence Positions: 8-37
• Sequence Length: 384

• Applicable Applications for anti-S1PR4 antibody: Western Blot (WB), ELISA (EIA)
• Application Notes: WB~~1:1000
• Antigen Type: Synthetic Peptide
• Antigen Source: HUMAN
• Preparation and Storage: Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C in small aliquots to prevent freeze-thaw cycles.

Western Blot (WB)

(EDG6 Antibody (R23) western blot analysis in NCI-H292 cell line lysates (35ug/lane).This demonstrates the EDG6 antibody detected the EDG6 protein (arrow).)

Western Blot (WB)

(EDG6 Antibody (R23) western blot analysis in mouse spleen tissue lysates (35ug/lane).This demonstrates the EDG6 antibody detected the EDG6 protein (arrow).)

Related Product Information for anti-S1PR4 antibody

EDG6 is a member of the G protein-coupled receptors, as well as the EDG family of proteins. It participates in endothelial differentiation, and may regulate lymphocyte cell signaling. It is a member of the lysophospholipid/lysosphingolipid receptor family.

Product Categories/Family for anti-S1PR4 antibody

Metabolism; Signal Transduction; Phospho Antibodies

References

Contos, J.J., et al., FEBS Lett. 531(1):99-102 (2002).
Yamazaki, Y., et al., Biochem. Biophys. Res. Commun. 268(2):583-589 (2000).
Graler, M.H., et al., Genomics 53(2):164-169 (1998).

NCBI and Uniprot Product Information

• NCBI GI #: 4503459
• NCBI GeneID: 8698
• NCBI Accession #: NP_003766.1
• NCBI GenBank Nucleotide #: NM_003775.3
• UniProt Accession #: O95977; D6W612
• Molecular Weight: 41623
• NCBI Official Full Name: sphingosine 1-phosphate receptor 4
• NCBI Official Synonym Full Names: sphingosine-1-phosphate receptor 4
• NCBI Official Symbol: S1PR4
• NCBI Official Synonym Symbols: EDG6; LPC1; S1P4; SLP4
• NCBI Protein Information: sphingosine 1-phosphate receptor 4
• UniProt Protein Name: Sphingosine 1-phosphate receptor 4
• Protein Family: Sphingosine 1-phosphate receptor
• UniProt Gene Name: S1PR4
• UniProt Synonym Gene Names: EDG6; S1P receptor 4; S1P4; S1P receptor Edg-6
• UniProt Entry Name: S1PR4_HUMAN

NCBI Description

This gene is a member of the endothelial differentiation, G-protein-coupled (EDG)) receptor gene family. EDG receptors bind lysophospholipids or lysosphingolipids as ligands, and are involved in cell signalling in many different cell types. This EDG receptor gene is intronless and is specifically expressed in the lymphoid tissue. [provided by RefSeq, Jul 2008]

Uniprot Description

S1PR4: Receptor for the lysosphingolipid sphingosine 1- phosphate (S1P). S1P is a bioactive lysophospholipid that elicits diverse physiological effect on most types of cells and tissues. May be involved in cell migration processes that are specific for lymphocytes. Belongs to the G-protein coupled receptor 1 family.

Protein type: GPCR, family 1; Membrane protein, multi-pass; Membrane protein, integral; Receptor, GPCR

Chromosomal Location of Human Ortholog: 19p13.3

Cellular Component: integral to plasma membrane; plasma membrane

Molecular Function: G-protein coupled receptor activity; lipid binding

Biological Process: G-protein coupled receptor protein signaling pathway; elevation of cytosolic calcium ion concentration; phospholipase C activation; immune response; G-protein signaling, adenylate cyclase activating pathway