Western Blot (WB)
(PPRC1 Antibody (C-term) western blot analysis in Jurkat cell line lysates (35ug/lane).This demonstrates the PPRC1 antibody detected the PPRC1 protein (arrow).)
Rabbit PPRC1 Polyclonal Antibody | anti-PPRC1 antibody
PPRC1 Antibody (C-term)
Western Blot (WB)
(PPRC1 Antibody (C-term) western blot analysis in Jurkat cell line lysates (35ug/lane).This demonstrates the PPRC1 antibody detected the PPRC1 protein (arrow).)
Western Blot (WB)
(PPRC1 Antibody (C-term) western blot analysis in Jurkat cell line lysates (35ug/lane).This demonstrates the PPRC1 antibody detected the PPRC1 protein (arrow).)
Immunohistochemistry (IHC)
(PPRC1 antibody (C-term) immunohistochemistry analysis in formalin fixed and paraffin embedded human lung carcinoma followed by peroxidase conjugation of the secondary antibody and DAB staining. This data demonstrates the use of the PPRC1 antibody (C-term) for immunohistochemistry. Clinical relevance has not been evaluated.)
Immunohistochemistry (IHC)
(PPRC1 antibody (C-term) immunohistochemistry analysis in formalin fixed and paraffin embedded human lung carcinoma followed by peroxidase conjugation of the secondary antibody and DAB staining. This data demonstrates the use of the PPRC1 antibody (C-term) for immunohistochemistry. Clinical relevance has not been evaluated.)
coactivator 1 (PPARGC1/PGC-1), a protein that can activate
mitochondrial biogenesis in part through a direct interaction with
nuclear respiratory factor 1 (NRF1). This protein has been shown to
interact with NRF1. It is thought to be a functional relative of
PPARGC1 that activates mitochondrial biogenesis through NRF1 in
response to proliferative signals.
Vercauteren, K., et al. J. Biol. Chem. 284(4):2307-2319(2009)
Raharijaona, M., et al. PLoS ONE 4 (11), E7964 (2009) :
Lu, Y., et al. J. Lipid Res. 49(12):2582-2589(2008)
Vercauteren, K., et al. J. Biol. Chem. 283(18):12102-12111(2008)
NCBI and Uniprot Product Information
NCBI Description
The protein encoded by this gene is similar to PPAR-gamma coactivator 1 (PPARGC1/PGC-1), a protein that can activate mitochondrial biogenesis in part through a direct interaction with nuclear respiratory factor 1 (NRF1). This protein has been shown to interact with NRF1. It is thought to be a functional relative of PPAR-gamma coactivator 1 that activates mitochondrial biogenesis through NRF1 in response to proliferative signals. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2013]
Uniprot Description
PPRC1: Acts as a coactivator during transcriptional activation of nuclear genes related to mitochondrial biogenesis and cell growth. Involved in the transcription coactivation of CREB and NRF1 target genes. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Transcription, coactivator/corepressor
Chromosomal Location of Human Ortholog: 10q24.32
Cellular Component: nucleoplasm
Molecular Function: ligand-dependent nuclear receptor transcription coactivator activity; nucleotide binding; transcription factor binding
Biological Process: transcription from RNA polymerase II promoter; mitochondrion organization and biogenesis; organelle organization and biogenesis; positive regulation of transcription factor activity; positive regulation of transcription from RNA polymerase II promoter
Research Articles on PPRC1
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Product Notes
The PPRC1 pprc1 (Catalog #AAA9203548) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 1636-1664. The PPRC1 Antibody (C-term) reacts with Human (Predicted Reactivity: Mouse) and may cross-react with other species as described in the data sheet. AAA Biotech's PPRC1 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), ELISA (EIA), Immunohistochemistry (IHC). WB~~1:1000. Researchers should empirically determine the suitability of the PPRC1 pprc1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "PPRC1, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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