Rabbit anti-Rat TYRO3 Polyclonal Antibody | anti-TYRO3 antibody

TYRO3 Antibody (C-term)

Cat. Num. AAA9202907

• Gene Names: TYRO3; BYK; Dtk; RSE; Rek; Sky; Tif; Etk-2
• Reactivity: Rat
• Applications: Western Blot, ELISA
• Purity: Purified Rabbit Polyclonal Antibody (Pab)
• Synonyms: TYRO3; Polyclonal Antibody; TYRO3 Antibody (C-term); Tyrosine-protein kinase receptor TYRO3; Tyrosine-protein kinase BYK; Tyrosine-protein kinase DTK; Tyrosine-protein kinase RSE; Tyrosine-protein kinase SKY; Tyrosine-protein kinase TIF; BYK; DTK; RSE; SKY; TIF; anti-TYRO3 antibody

• Host: Rabbit
• Reactivity: Rat
• Clonality: Polyclonal
• Isotype: Rabbit Ig
• Specificity: This TYRO3 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 854-878 amino acids from the C-terminal region of human TYRO3.
• Purity/Purification: Purified Rabbit Polyclonal Antibody (Pab)
• Form/Format: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
• Concentration: Vial Concentration: 0.5 (varies by lot)
• Sequence Length: 890

• Applicable Applications for anti-TYRO3 antibody: Western Blot (WB), ELISA (EIA)
• Application Notes: WB~~1:500
• Antigen Source: HUMAN
• Preparation and Storage: Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C in small aliquots to prevent freeze-thaw cycles.

Western Blot (WB)

(Western blot analysis of lysate from rat brain tissue lysate, using TYRO3 Antibody (C-term). MBS9202907 was diluted at 1:500. A goat anti-rabbit IgG H&L(HRP) at 1:10000 dilution was used as the secondary antibody. Lysate at 20ug.)

Related Product Information for anti-TYRO3 antibody

Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to several ligands including TULP1 or GAS6. Regulates many physiological processes including cell survival, migration and differentiation. Ligand binding at the cell surface induces dimerization and autophosphorylation of TYRO3 on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with PIK3R1 and thereby enhances PI3-kinase activity. Activates the AKT survival pathway, including nuclear translocation of NF-kappa-B and up-regulation of transcription of NF-kappa-B-regulated genes. TYRO3 signaling plays a role in various processes such as neuron protection from excitotoxic injury, platelet aggregation and cytoskeleton reorganization. Plays also an important role in inhibition of Toll-like receptors (TLRs)-mediated innate immune response by activating STAT1, which selectively induces production of suppressors of cytokine signaling SOCS1 and SOCS3.

Product Categories/Family for anti-TYRO3 antibody

Cell Biology; Metabolism

References

Mark M.R.,et al.J. Biol. Chem. 269:10720-10728(1994).
Ohashi K.,et al.Oncogene 9:699-705(1994).
Crosier K.E.,et al.Growth Factors 11:137-144(1994).
Kajii Y.,et al.Biol. Cell 88:45-54(1996).
Polvi A.,et al.Gene 134:289-293(1993).

NCBI and Uniprot Product Information

• NCBI GI #: 27597078
• NCBI GeneID: 7301
• NCBI Accession #: NP_006284.2
• NCBI GenBank Nucleotide #: NM_006293.3
• UniProt Accession #: Q06418; O14953; Q86VR3
• Molecular Weight: 96905
• NCBI Official Full Name: tyrosine-protein kinase receptor TYRO3
• NCBI Official Synonym Full Names: TYRO3 protein tyrosine kinase
• NCBI Official Symbol: TYRO3
• NCBI Official Synonym Symbols: BYK; Dtk; RSE; Rek; Sky; Tif; Etk-2
• NCBI Protein Information: tyrosine-protein kinase receptor TYRO3
• UniProt Protein Name: Tyrosine-protein kinase receptor TYRO3
• Protein Family: Tyrosine-protein kinase receptor
• UniProt Gene Name: TYRO3
• UniProt Synonym Gene Names: BYK; DTK; RSE; SKY; TIF
• UniProt Entry Name: TYRO3_HUMAN

NCBI Description

The gene is part of a 3-member transmembrane receptor kinase receptor family with a processed pseudogene distal on chromosome 15. The encoded protein is activated by the products of the growth arrest-specific gene 6 and protein S genes and is involved in controlling cell survival and proliferation, spermatogenesis, immunoregulation and phagocytosis. The encoded protein has also been identified as a cell entry factor for Ebola and Marburg viruses. [provided by RefSeq, May 2010]

Uniprot Description

Tyro3: Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to several ligands including TUB, TULP1 or GAS6. Regulates many physiological processes including cell survival, migration and differentiation. Ligand binding at the cell surface induces dimerization and autophosphorylation of TYRO3 on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with PIK3R1 and thereby enhances PI3-kinase activity. Activates the AKT survival pathway, including nuclear translocation of NF-kappa-B and up-regulation of transcription of NF-kappa-B-regulated genes. TYRO3 signaling plays a role in various processes such as neuron protection from excitotoxic injury, platelet aggregation and cytoskeleton reorganization. Plays also an important role in inhibition of Toll-like receptors (TLRs)-mediated innate immune response by activating STAT1, which selectively induces production of suppressors of cytokine signaling SOCS1 and SOCS3. Monomer and homodimer. Interacts (via N-terminus) with extracellular ligands TUB, TULP1 and GAS6. Interacts with PIK3R1; this interaction increases PI3-kinase activity. Abundant in the brain and lower levels in other tissues. Belongs to the protein kinase superfamily. Tyr protein kinase family. AXL/UFO subfamily.

Protein type: Protein kinase, tyrosine (receptor); EC 2.7.10.1; Protein kinase, TK; Kinase, protein; Membrane protein, integral; TK group; Axl family

Chromosomal Location of Human Ortholog: 15q15

Cellular Component: endoplasmic reticulum membrane; integral to plasma membrane; nuclear envelope; nucleus

Molecular Function: protein binding; protein heterodimerization activity; protein-tyrosine kinase activity; phosphoinositide 3-kinase binding; transmembrane receptor protein tyrosine kinase activity; receptor signaling protein tyrosine kinase activity; ATP binding

Biological Process: forebrain cell migration; platelet activation; negative regulation of lymphocyte activation; phosphoinositide 3-kinase cascade; peptidyl-tyrosine phosphorylation; protein amino acid autophosphorylation; vagina development; signal transduction; ovulation cycle; natural killer cell differentiation; negative regulation of innate immune response; negative regulation of inflammatory response; protein kinase B signaling cascade; negative regulation of toll-like receptor signaling pathway; spermatogenesis; negative regulation of neuron apoptosis; cell adhesion; apoptotic cell clearance; secretion by cell