Western Blot (WB)
(APH1A Antibody (N-term) western blot analysis in mouse liver tissue lysates (35ug/lane).This demonstrates the APH1A antibody detected the APH1A protein (arrow).)
Rabbit anti-Mouse APH1A Polyclonal Antibody | anti-APH1A antibody
APH1A Antibody (N-term)
Western Blot (WB)
(APH1A Antibody (N-term) western blot analysis in mouse liver tissue lysates (35ug/lane).This demonstrates the APH1A antibody detected the APH1A protein (arrow).)
Western Blot (WB)
(APH1A Antibody (N-term) western blot analysis in mouse liver tissue lysates (35ug/lane).This demonstrates the APH1A antibody detected the APH1A protein (arrow).)
with presenilin (see PSEN1; MIM 104311) and nicastrin (APH2; MIM
605254) as a functional component of the gamma-secretase complex.
The gamma-secretase complex is required for the intramembrane
proteolysis of a number of membrane proteins, including the
amyloid-beta precursor protein (APP; MIM 104760) and Notch (MIM
190198).
Mitsuishi, Y., et al. J. Biol. Chem. 285(20):14920-14931(2010)
Chen, A.C., et al. J. Biol. Chem. 285(15):11378-11391(2010)
Pardossi-Piquard, R., et al. J. Biol. Chem. 284(24):16298-16307(2009)
Wang, Y., et al. Neurosci. Lett. 455(2):101-104(2009)
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a component of the gamma secretase complex that cleaves integral membrane proteins such as Notch receptors and beta-amyloid precursor protein. The gamma secretase complex contains this gene product, or the paralogous anterior pharynx defective 1 homolog B (APH1B), along with the presenilin, nicastrin, and presenilin enhancer-2 proteins. The precise function of this seven-transmembrane-domain protein is unknown though it is suspected of facilitating the association of nicastrin and presenilin in the gamma secretase complex as well as interacting with substrates of the gamma secretase complex prior to their proteolytic processing. Polymorphisms in a promoter region of this gene have been associated with an increased risk for developing sporadic Alzheimer's disease. Alternative splicing results in multiple protein-coding and non-protein-coding transcript variants. [provided by RefSeq, Aug 2011]
Uniprot Description
APH1A: Essential subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral proteins such as Notch receptors and APP (beta-amyloid precursor protein). It probably represents a stabilizing cofactor for the presenilin homodimer that promotes the formation of a stable complex. Belongs to the APH-1 family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Membrane protein, multi-pass; Apoptosis; Membrane protein, integral; Endoplasmic reticulum
Chromosomal Location of Human Ortholog: 1p36.13-q31.3
Cellular Component: Golgi apparatus; endoplasmic reticulum membrane; membrane; endoplasmic reticulum; integral to plasma membrane; plasma membrane
Molecular Function: protein binding; endopeptidase activity
Biological Process: positive regulation of catalytic activity; axon guidance; amyloid precursor protein catabolic process; Notch signaling pathway; membrane protein intracellular domain proteolysis; nerve growth factor receptor signaling pathway; positive regulation of apoptosis; membrane protein ectodomain proteolysis; ephrin receptor signaling pathway; Notch receptor processing; protein processing; metanephros development
Research Articles on APH1A
Similar Products
Product Notes
The APH1A aph1a (Catalog #AAA9200854) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 41-70. The APH1A Antibody (N-term) reacts with Mouse and may cross-react with other species as described in the data sheet. AAA Biotech's APH1A can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), ELISA (EIA). WB~~1:1000. Researchers should empirically determine the suitability of the APH1A aph1a for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "APH1A, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
If you are ready to order, navigate to Shopping Cart and get ready to checkout.
