Western Blot (WB)
(RAB21 Antibody (C-term) western blot analysis in Ramos cell line lysates (35ug/lane).This demonstrates the RAB21 antibody detected the RAB21 protein (arrow).)
Rabbit RAB21 Polyclonal Antibody | anti-RAB21 antibody
RAB21 Antibody (C-term)
Western Blot (WB)
(RAB21 Antibody (C-term) western blot analysis in Ramos cell line lysates (35ug/lane).This demonstrates the RAB21 antibody detected the RAB21 protein (arrow).)
Western Blot (WB)
(RAB21 Antibody (C-term) western blot analysis in Ramos cell line lysates (35ug/lane).This demonstrates the RAB21 antibody detected the RAB21 protein (arrow).)
Immunohistochemistry (IHC)
(RAB21 Antibody (C-term) immunohistochemistry analysis in formalin fixed and paraffin embedded human colon carcinoma followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of RAB21 Antibody (C-term) for immunohistochemistry. Clinical relevance has not been evaluated.)
Immunohistochemistry (IHC)
(RAB21 Antibody (C-term) immunohistochemistry analysis in formalin fixed and paraffin embedded human colon carcinoma followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of RAB21 Antibody (C-term) for immunohistochemistry. Clinical relevance has not been evaluated.)
proteins that regulate intracellular vesicle targeting (Opdam et
al., 2000 [PubMed 10887961]).
Pellinen, T., et al. Dev. Cell 15(3):371-385(2008)
Delprato, A., et al. Nat. Struct. Mol. Biol. 14(5):406-412(2007)
Pellinen, T., et al. J. Cell Biol. 173(5):767-780(2006)
Eathiraj, S., et al. Nature 436(7049):415-419(2005)
NCBI and Uniprot Product Information
NCBI Description
This gene belongs to the Rab family of monomeric GTPases, which are involved in the control of cellular membrane traffic. The encoded protein plays a role in the targeted trafficking of integrins via its association with integrin alpha tails. As a consequence, the encoded protein is involved in the regulation of cell adhesion and migration. [provided by RefSeq, Aug 2013]
Uniprot Description
RAB21: Regulates integrin internalization and recycling, but does not influence the traffic of endosomally translocated receptors in general. As a result, may regulate cell adhesion and migration. During the mitosis of adherent cells, controls the endosomal trafficking of integrins which is required for the successful completion of cytokinesis. Belongs to the small GTPase superfamily. Rab family.
Protein type: G protein, monomeric, Rab; G protein, monomeric; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 12q21.1
Cellular Component: endoplasmic reticulum membrane; internal side of plasma membrane; cytoplasmic vesicle membrane; focal adhesion; early endosome; trans-Golgi network; vesicle membrane; endosome; cleavage furrow
Molecular Function: GTPase activity; protein binding; GDP binding; GTP binding
Biological Process: regulation of exocytosis; intracellular protein transport; metabolic process; regulation of endocytosis; Rab protein signal transduction; positive regulation of receptor-mediated endocytosis
Research Articles on RAB21
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Product Notes
The RAB21 rab21 (Catalog #AAA9200750) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 168-197. The RAB21 Antibody (C-term) reacts with Human (Predicted Reactivity: Bovine, Mouse, Rat) and may cross-react with other species as described in the data sheet. AAA Biotech's RAB21 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), ELISA (EIA), Immunohistochemistry (IHC). WB~~1:1000. Researchers should empirically determine the suitability of the RAB21 rab21 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "RAB21, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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