Rabbit anti-Human, Mouse ADGRG1 Polyclonal Antibody | anti-ADGRG1 antibody

ADGRG1 Rabbit pAb

Cat. Num. AAA9143310

• Gene Names: GPR56; BFPP; BPPR; TM7LN4; TM7XN1
• Reactivity: Human, Mouse
• Applications: Western Blot
• Purity: Affinity purification
• Synonyms: ADGRG1; Polyclonal Antibody; ADGRG1 Rabbit pAb; BFPP; BPPR; GPR56; TM7LN4; TM7XN1; anti-ADGRG1 antibody

• Host: Rabbit
• Reactivity: Human, Mouse
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Affinity purification
• Form/Format: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

• Applicable Applications for anti-ADGRG1 antibody: Western Blot (WB)
• Application Notes: WB: 1:500-1:2000
• Immunogen: Recombinant protein of human ADGRG1.
• Preparation and Storage: Store at -20 degree C. Avoid freeze/thaw cycles.

Product Categories/Family for anti-ADGRG1 antibody

Signal Transduction; G protein signaling; G-Protein-Coupled Receptors(GPCR)

NCBI and Uniprot Product Information

• NCBI GI #: 41584200
• NCBI GeneID: 9289
• NCBI Accession #: NP_005673.3
• NCBI GenBank Nucleotide #: NM_005682.6
• UniProt Accession #: Q9Y653; O95966; Q6ZMP1; Q8NGB3; Q96HB4; A6NIT7; A6NJV9; B0M0K4; B4DR54
• Molecular Weight: 58,042 Da
• NCBI Official Full Name: G-protein coupled receptor 56 isoform a
• NCBI Official Synonym Full Names: G protein-coupled receptor 56
• NCBI Official Symbol: GPR56
• NCBI Official Synonym Symbols: BFPP; BPPR; TM7LN4; TM7XN1
• NCBI Protein Information: G-protein coupled receptor 56; 7-transmembrane protein with no EGF-like N-terminal domains-1
• UniProt Protein Name: G-protein coupled receptor 56
• Protein Family: Adhesion G protein-coupled receptor
• UniProt Gene Name: GPR56
• UniProt Synonym Gene Names: TM7LN4; TM7XN1; GPR56 NT; GPR56(N); GPR56 CT; GPR56(C); GPR56 7TM
• UniProt Entry Name: GPR56_HUMAN

NCBI Description

This gene encodes a member of the G protein-coupled receptor family and regulates brain cortical patterning. The encoded protein binds specifically to transglutaminase 2, a component of tissue and tumor stroma implicated as an inhibitor of tumor progression. Mutations in this gene are associated with a brain malformation known as bilateral frontoparietal polymicrogyria. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2014]

Uniprot Description

GPR56: Could be involved in cell-cell interactions. Defects in GPR56 are the cause of bilateral frontoparietal polymicrogyria (BFPP). BFPP is characterized by disorganized cortical lamination that is most severe in frontal cortex. Belongs to the G-protein coupled receptor 2 family. LN-TM7 subfamily. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, multi-pass; Membrane protein, integral; Receptor, GPCR; GPCR, family 2; Cell adhesion

Chromosomal Location of Human Ortholog: 16q21

Cellular Component: integral to plasma membrane; integral to membrane

Molecular Function: collagen binding; G-protein coupled receptor activity; extracellular matrix binding

Biological Process: negative regulation of cell proliferation; G-protein coupled receptor protein signaling pathway; positive regulation of cell adhesion; cell-cell signaling; cerebral cortex radial glia guided migration; positive regulation of Rho protein signal transduction; angiogenesis; brain development; cell adhesion; layer formation in the cerebral cortex; Rho protein signal transduction

Disease: Polymicrogyria, Bilateral Frontoparietal; Polymicrogyria, Bilateral Perisylvian, Autosomal Recessive