anti-Human NCOR2 Antibody | anti-NCOR2 antibody

NCOR2 Antibody

Cat. Num. AAA858700

• Gene Names: NCOR2; SMRT; TRAC; CTG26; SMRTE; TRAC1; N-CoR2; TNRC14; TRAC-1; SMAP270; SMRTE-tau
• Reactivity: Human
• Applications: Immunohistochemistry, Immunofluorescence, ELISA
• Purity: Affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
• Synonyms: NCOR2; NCOR2 Antibody; CTG repeat protein 26; N-CoR2; NCR2; Nuclear receptor corepressor 2; SMAP270; SMRTe; Silencing mediator of retinoic acid and thyroid hormone receptor; T3 receptor-associating factor; TRAC; Thyroid-; retinoic-acid-receptor-associated corepressor; anti-NCOR2 antibody

• Reactivity: Human
• Specificity: NCOR2 antibody detects endogenous levels of total NCOR2 protein.
• Purity/Purification: Affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
• Form/Format: In phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
• Sequence Length: 2458

• Applicable Applications for anti-NCOR2 antibody: Immunohistochemistry (IHC), Immunofluorescence (IF), ELISA (EIA)
• Application Notes: IHC: 1:50-1:100; IF: 1:00-1:500; ELISA: 1:20000
• Immunogen: The antiserum was produced against synthesized peptide derived from internal of human NCOR2.
• Preparation and Storage: Store at-20 degree C for 1 year.

Testing Data

(Peptide-+)

Immunohistochemistry (IHC)

(Peptide-+ Immunohistochemistry analysis of paraffin-embedded human brain tissue, using NCOR2 antibody. Immunofluorescence analysis of A549 cells, using NCOR2 antibody.)

Product Categories/Family for anti-NCOR2 antibody

Autophagy antibody; Cancer; Cardiovascular; Cell Biology; Epigenetics & Nuclear Signaling; Developmental Biologys; Immunology; Drug Discovery Products; Metabolism; Neuroscience; Signal Transduction; Stem Cells

References

Guenther M.G., Genes Dev. 14:1048-1057(2000). Li J., EMBO J. 19:4342-4350(2000). Fischer D.D., J. Biol. Chem. 277:6656-6666(2002).

NCBI and Uniprot Product Information

• NCBI GI #: 331284176
• NCBI GeneID: 9612
• NCBI Accession #: NP_001070729.2
• NCBI GenBank Nucleotide #: NM_001077261.3
• UniProt Accession #: Q9Y618; O00613; O15416; O15421; Q13354; Q56D06; Q59GM0; Q9Y5U0
• Molecular Weight: 268,361 Da
• NCBI Official Full Name: nuclear receptor corepressor 2 isoform 2
• NCBI Official Synonym Full Names: nuclear receptor corepressor 2
• NCBI Official Symbol: NCOR2
• NCBI Official Synonym Symbols: SMRT; TRAC; CTG26; SMRTE; TRAC1; N-CoR2; TNRC14; TRAC-1; SMAP270; SMRTE-tau
• NCBI Protein Information: nuclear receptor corepressor 2
• UniProt Protein Name: Nuclear receptor corepressor 2
• Protein Family: Nuclear receptor corepressor
• UniProt Gene Name: NCOR2
• UniProt Synonym Gene Names: CTG26; N-CoR2; SMRT; TRAC

NCBI Description

This gene encodes a nuclear receptor co-repressor that mediates transcriptional silencing of certain target genes. The encoded protein is a member of a family of thyroid hormone- and retinoic acid receptor-associated co-repressors. This protein acts as part of a multisubunit complex which includes histone deacetylases to modify chromatin structure that prevents basal transcriptional activity of target genes. Aberrant expression of this gene is associated with certain cancers. Alternate splicing results in multiple transcript variants encoding different isoforms.[provided by RefSeq, Apr 2011]

Uniprot Description

Transcriptional corepressor. Mediates the transcriptional repression activity of some nuclear receptors by promoting chromatin condensation, thus preventing access of the basal transcription. Isoform 1 and isoform 5 have different affinities for different nuclear receptors. Involved in the regulation BCL6-dependent of the germinal center (GC) reactions, mainly through the control of the GC B-cells proliferation and survival.