anti-Human Cadherin EGF LAG seven-pass G-type receptor 2 Polyclonal Antibody | anti-CELSR2 antibody

Cadherin EGF LAG seven-pass G-type receptor 2 Antibody

Cat. Num. AAA857006

• Gene Names: CELSR2; EGFL2; MEGF3; ADGRC2; CDHF10; Flamingo1
• Reactivity: Human
• Applications: Western Blot, Immunocytochemistry
• Purity: Affinity Purified
• Synonyms: Cadherin EGF LAG seven-pass G-type receptor 2; Polyclonal Antibody; Cadherin EGF LAG seven-pass G-type receptor 2 Antibody; anti-CELSR2 antibody

• Reactivity: Human
• Clonality: Polyclonal
• Specificity: This antibody is produced by immunizing rabbits with a synthetic peptide (KLH-coupled) corresponding to CELSR2.
• Purity/Purification: Affinity Purified
• Form/Format: Liquid
• Sequence Length: 2923

• Applicable Applications for anti-CELSR2 antibody: Western Blot (WB), Immunocytochemistry (ICC)
• Application Notes: WB: 1:250~1:500; ICC: 1:50-1:100
• Cellular Localization: Cell Membrane
• Positive Control: Recombinant protein
• Preparation and Storage: Store at +4 degree C after thawing. Aliquot store at-20 degree C or-80 degree C. Avoid repeated freeze/thaw cycles.

Testing Data

(Western blot analysis on recombinant protein of CELSR2 using anti- CELSR2 polyclonal antibody.)

Related Product Information for anti-CELSR2 antibody

Cadherin EGF LAG seven-pass G-type receptor 2 belongs to the G-protein coupled receptor 2 family, highest expressed in brain and testis. The protein encoded by the gene CELSR2 is a member of the flamingo subfamily, part of the cadherin superfamily. It may have an important role in cell/cell signaling during nervous system formation.

References

1. "The human homologue of flamingo, EGFL2, encodes a brain-expressed large cadherin-like protein with epidermal growth factor-like domains, and maps to chromosome 1p13.3-p21.1."Vincent J.B., Skaug J., Scherer S.W.DNA Res. 7:233-235(2000). 2. "Prediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain."Nagase T., Seki N., Ishikawa K., Ohira M., Kawarabayasi Y., Ohara O., Tanaka A., Kotani H., Miyajima N., Nomura N.DNA Res. 3:321-329(1996).

NCBI and Uniprot Product Information

• NCBI GI #: 13325064
• NCBI GeneID: 1952
• NCBI Accession #: NP_001399.1
• NCBI GenBank Nucleotide #: NM_001408.2
• UniProt Accession #: Q9HCU4; Q5T2Y7; Q92566
• Molecular Weight: 48kDa
• NCBI Official Full Name: cadherin EGF LAG seven-pass G-type receptor 2
• NCBI Official Synonym Full Names: cadherin EGF LAG seven-pass G-type receptor 2
• NCBI Official Symbol: CELSR2
• NCBI Official Synonym Symbols: EGFL2; MEGF3; ADGRC2; CDHF10; Flamingo1
• NCBI Protein Information: cadherin EGF LAG seven-pass G-type receptor 2
• UniProt Protein Name: Cadherin EGF LAG seven-pass G-type receptor 2
• Protein Family: Cadherin EGF LAG seven-pass G-type receptor
• UniProt Gene Name: CELSR2
• UniProt Synonym Gene Names: CDHF10; EGFL2; KIAA0279; MEGF3; EGF-like protein 2; Multiple EGF-like domains protein 3

NCBI Description

The protein encoded by this gene is a member of the flamingo subfamily, part of the cadherin superfamily. The flamingo subfamily consists of nonclassic-type cadherins; a subpopulation that does not interact with catenins. The flamingo cadherins are located at the plasma membrane and have nine cadherin domains, seven epidermal growth factor-like repeats and two laminin A G-type repeats in their ectodomain. They also have seven transmembrane domains, a characteristic unique to this subfamily. It is postulated that these proteins are receptors involved in contact-mediated communication, with cadherin domains acting as homophilic binding regions and the EGF-like domains involved in cell adhesion and receptor-ligand interactions. The specific function of this particular member has not been determined. [provided by RefSeq, Jul 2008]

Uniprot Description

Receptor that may have an important role in cell/cell signaling during nervous system formation.