Rabbit anti-Mouse KLK2 Polyclonal Antibody | anti-KLK2 antibody

KLK2 Polyclonal Antibody

Cat. Num. AAA8567202

• Gene Names: KLK2; hK2; hGK-1; KLK2A2
• Reactivity: Mouse
• Applications: Western Blot
• Purity: Affinity Purification
• Synonyms: KLK2; Polyclonal Antibody; KLK2 Polyclonal Antibody; anti-KLK2 antibody

• Host: Rabbit
• Reactivity: Mouse
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Affinity Purification
• Form/Format: PBS with 0.02% sodium azide, 50% glycerol, pH 7.3.
• Sequence Length: 261

• Applicable Applications for anti-KLK2 antibody: Western Blot (WB)
• Application Notes: WB: 1:500-1:2000
• Immunogen: Recombinant protein of human KLK2 (NP_005542.1).
• Preparation and Storage: Store at -20 degree C. Avoid freeze/thaw cycles.

Related Product Information for anti-KLK2 antibody

This gene encodes a member of the grandular kallikrein protein family. Kallikreins are a subgroup of serine proteases that are clustered on chromosome 19. Members of this family are involved in a diverse array of biological functions. The protein encoded by this gene is a highly active trypsin-like serine protease that selectively cleaves at arginine residues. This protein is primarily expressed in prostatic tissue and is responsible for cleaving pro-prostate-specific antigen into its enzymatically active form. This gene is highly expressed in prostate tumor cells and may be a prognostic maker for prostate cancer risk. Alternate splicing results in both coding and non-coding transcript variants.

NCBI and Uniprot Product Information

• NCBI GI #: 5031829
• NCBI GeneID: 3817
• NCBI Accession #: NP_005542.1
• NCBI GenBank Nucleotide #: NP_005542.1
• UniProt Accession #: P20151
• Molecular Weight: 17kDa; 18kDa; 24kDa; 28kDa
• NCBI Official Full Name: kallikrein-2 isoform 1 preproprotein
• NCBI Official Synonym Full Names: kallikrein related peptidase 2
• NCBI Official Symbol: KLK2
• NCBI Official Synonym Symbols: hK2; hGK-1; KLK2A2
• NCBI Protein Information: kallikrein-2
• UniProt Protein Name: Kallikrein-2
• Protein Family: Kallikrein
• UniProt Gene Name: KLK2
• UniProt Synonym Gene Names: hGK-1
• UniProt Entry Name: KLK2_HUMAN

NCBI Description

This gene encodes a member of the grandular kallikrein protein family. Kallikreins are a subgroup of serine proteases that are clustered on chromosome 19. Members of this family are involved in a diverse array of biological functions. The protein encoded by this gene is a highly active trypsin-like serine protease that selectively cleaves at arginine residues. This protein is primarily expressed in prostatic tissue and is responsible for cleaving pro-prostate-specific antigen into its enzymatically active form. This gene is highly expressed in prostate tumor cells and may be a prognostic maker for prostate cancer risk. Alternate splicing results in both coding and non-coding transcript variants. [provided by RefSeq, Jan 2012]

Uniprot Description

KLK2: Glandular kallikreins cleave Met-Lys and Arg-Ser bonds in kininogen to release Lys-bradykinin. Belongs to the peptidase S1 family. Kallikrein subfamily. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Protease; EC 3.4.21.35

Chromosomal Location of Human Ortholog: 19q13.41

Cellular Component: extracellular region

Molecular Function: serine-type endopeptidase activity

Biological Process: extracellular matrix disassembly; extracellular matrix organization and biogenesis; proteolysis